diff --git a/pkgs/development/compilers/gnatboot/default.nix b/pkgs/development/compilers/gnatboot/default.nix
index 65f6269e2f00..7ef2ce03df94 100644
--- a/pkgs/development/compilers/gnatboot/default.nix
+++ b/pkgs/development/compilers/gnatboot/default.nix
@@ -4,34 +4,53 @@
 }:
 
 let
-  versionMap = {
+  throwUnsupportedSystem = throw "Unsupported system: ${stdenv.hostPlatform.system}";
+
+  versionMap = rec {
     "11" = {
-      version = "11.2.0-4";
-      hash = "sha256-8fMBJp6igH+Md5jE4LMubDmC4GLt4A+bZG/Xcz2LAJQ=";
-    };
+      gccVersion = "11.2.0";
+      alireRevision = "4";
+    } // {
+      x86_64-darwin = {
+        hash = "sha256-FmBgD20PPQlX/ddhJliCTb/PRmKxe9z7TFPa2/SK4GY=";
+        upstreamTriplet = "x86_64-apple-darwin19.6.0";
+      };
+      x86_64-linux = {
+        hash = "sha256-8fMBJp6igH+Md5jE4LMubDmC4GLt4A+bZG/Xcz2LAJQ=";
+        upstreamTriplet = "x86_64-pc-linux-gnu";
+      };
+    }.${stdenv.hostPlatform.system} or throwUnsupportedSystem;
     "12" = {
-      version = "12.1.0-2";
-      hash = "sha256-EPDPOOjWJnJsUM7GGxj20/PXumjfLoMIEFX1EDtvWVY=";
-    };
+      gccVersion = "12.1.0";
+      alireRevision = "2";
+    } // {
+      x86_64-darwin = {
+        hash = "sha256-zrcVFvFZMlGUtkG0p1wST6kGInRI64Icdsvkcf25yVs=";
+        upstreamTriplet = "x86_64-apple-darwin19.6.0";
+      };
+      x86_64-linux = {
+        hash = "sha256-EPDPOOjWJnJsUM7GGxj20/PXumjfLoMIEFX1EDtvWVY=";
+        upstreamTriplet = "x86_64-pc-linux-gnu";
+      };
+    }.${stdenv.hostPlatform.system} or throwUnsupportedSystem;
   };
 
 in with versionMap.${majorVersion};
 
 stdenv.mkDerivation rec {
   pname = "gnatboot";
-  inherit version;
+  inherit gccVersion alireRevision;
+
+  version = "${gccVersion}-${alireRevision}";
 
   src = fetchzip {
-    url = "https://github.com/alire-project/GNAT-FSF-builds/releases/download/gnat-${version}/gnat-x86_64-linux-${version}.tar.gz";
+    url = "https://github.com/alire-project/GNAT-FSF-builds/releases/download/gnat-${version}/gnat-${stdenv.hostPlatform.system}-${version}.tar.gz";
     inherit hash;
   };
 
   nativeBuildInputs = [
-    autoPatchelfHook
     dejagnu
-    elfutils
     expat
-    glibc
     gmp
     guile
     libipt
@@ -42,11 +61,69 @@ stdenv.mkDerivation rec {
     sourceHighlight
     xz
     zlib
+  ] ++ lib.optional stdenv.buildPlatform.isLinux [
+    autoPatchelfHook
+    elfutils
+    glibc
   ];
 
+  postPatch = lib.optionalString (stdenv.hostPlatform.isDarwin) ''
+    substituteInPlace lib/gcc/${upstreamTriplet}/${gccVersion}/install-tools/mkheaders.conf \
+      --replace "SYSTEM_HEADER_DIR=\"/usr/include\"" "SYSTEM_HEADER_DIR=\"/include\""
+  ''
+  # The included fixincl binary that is called during header fixup has a
+  # hardcoded execvp("/usr/bin/sed", ...) call, but /usr/bin/sed isn't
+  # available in the Nix Darwin stdenv.  Fortunately, execvp() will search the
+  # PATH environment variable for the executable if its first argument does not
+  # contain a slash, so we can just change the string to "sed" and zero the
+  # other bytes.
+  + ''
+     sed -i "s,/usr/bin/sed,sed\x00\x00\x00\x00\x00\x00\x00\x00\x00," libexec/gcc/${upstreamTriplet}/${gccVersion}/install-tools/fixincl
+  '';
+
   installPhase = ''
     mkdir -p $out
     cp -ar * $out/
+  ''
+
+  # So far with the Darwin gnatboot binary packages, there have been two
+  # types of dylib path references to other dylibs that need fixups:
+  #
+  # 1.  Dylibs in $out/lib with paths starting with
+  #     /Users/runner/.../gcc/install that refer to other dylibs in $out/lib
+  # 2.  Dylibs in $out/lib/gcc/*/*/adalib with paths starting with
+  #     @rpath that refer to other dylibs in $out/lib/gcc/*/*/adalib
+  #
+  # Additionally, per Section 14.4 Fixed Headers in the GCC 12.2.0 manual [2],
+  # we have to update the fixed header files in current Alire GCC package, since it
+  # was built against macOS 10.15 (Darwin 19.6.0), but Nix currently
+  # builds against macOS 10.12, and the two header file structures differ.
+  # For example, the current Alire GCC package has a fixed <stdio.h>
+  # from macOS 10.15 that contains a #include <_stdio.h>, but neither the Alire
+  # GCC package nor macOS 10.12 have such a header (<xlocale/_stdio.h> and
+  # <secure/_stdio.h> in 10.12 are not equivalent; indeed, 10.15 <_stdio.h>
+  # says it contains code shared by <stdio.h> and <xlocale/_stdio.h>).
+  #
+  # [2]: https://gcc.gnu.org/onlinedocs/gcc-12.2.0/gcc/Fixed-Headers.html
+
+  + lib.optionalString (stdenv.hostPlatform.isDarwin) ''
+    upstreamBuildPrefix="/Users/runner/work/GNAT-FSF-builds/GNAT-FSF-builds/sbx/x86_64-darwin/gcc/install"
+    for i in "$out"/lib/*.dylib "$out"/lib/gcc/*/*/adalib/*.dylib; do
+      if [[ -f "$i" && ! -h "$i" ]]; then
+        install_name_tool -id "$i" "$i" || true
+        for old_path in $(otool -L "$i" | grep "$upstreamBuildPrefix" | awk '{print $1}'); do
+          new_path=`echo "$old_path" | sed "s,$upstreamBuildPrefix,$out,"`
+          install_name_tool -change "$old_path" "$new_path" "$i" || true
+        done
+        for old_path in $(otool -L "$i" | grep "@rpath" | awk '{print $1}'); do
+          new_path=$(echo "$old_path" | sed "s,@rpath,$(dirname "$i"),")
+          install_name_tool -change "$old_path" "$new_path" "$i" || true
+        done
+      fi
+    done
+
+    "$out"/libexec/gcc/${upstreamTriplet}/${gccVersion}/install-tools/mkheaders -v -v \
+      "$out" "${stdenv.cc.libc}"
   '';
 
   passthru = {
@@ -54,6 +131,7 @@ stdenv.mkDerivation rec {
     langCC = false;
     langFortran = false;
     langAda = true;
+    isGNU = true;
   };
 
   meta = with lib; {
@@ -61,6 +139,6 @@ stdenv.mkDerivation rec {
     homepage = "https://www.gnu.org/software/gnat";
     license = licenses.gpl3;
     maintainers = with maintainers; [ ethindp ];
-    platforms = [ "x86_64-linux" ];
+    platforms = [ "x86_64-linux" "x86_64-darwin" ];
   };
 }