diff --git a/pkgs/development/python-modules/dnf4/default.nix b/pkgs/development/python-modules/dnf4/default.nix
new file mode 100644
index 000000000000..a40e22a4317f
--- /dev/null
+++ b/pkgs/development/python-modules/dnf4/default.nix
@@ -0,0 +1,83 @@
+{ lib
+, buildPythonPackage
+, cmake
+, fetchFromGitHub
+, gettext
+, libcomps
+, libdnf
+, python
+, rpm
+, sphinx
+}:
+
+buildPythonPackage rec {
+  pname = "dnf4";
+  version = "4.18.1";
+  format = "other";
+
+  outputs = [ "out" "man" ];
+
+  src = fetchFromGitHub {
+    owner = "rpm-software-management";
+    repo = "dnf";
+    rev = version;
+    hash = "sha256-pgS4y87HbFiaS+fftdhKHOZAl2hYTUds3XVXUuQN6tU=";
+  };
+
+  patches = [
+    ./fix-python-install-dir.patch
+  ];
+
+  postPatch = ''
+    substituteInPlace CMakeLists.txt \
+      --replace "@PYTHON_INSTALL_DIR@" "$out/${python.sitePackages}" \
+      --replace "SYSCONFDIR /etc" "SYSCONFDIR $out/etc" \
+      --replace "SYSTEMD_DIR /usr/lib/systemd/system" "SYSTEMD_DIR $out/lib/systemd/system"
+    substituteInPlace etc/tmpfiles.d/CMakeLists.txt \
+      --replace "DESTINATION /usr/lib/tmpfiles.d" "DESTINATION $out/usr/lib/tmpfiles.d"
+    substituteInPlace dnf/const.py.in \
+      --replace "/etc" "$out/etc"
+    substituteInPlace doc/CMakeLists.txt \
+      --replace 'SPHINX_BUILD_NAME "sphinx-build-3"' 'SPHINX_BUILD_NAME "${sphinx}/bin/sphinx-build"'
+  '';
+
+  nativeBuildInputs = [
+    cmake
+    gettext
+    sphinx
+  ];
+
+  propagatedBuildInputs = [
+    libcomps
+    libdnf
+    rpm
+  ];
+
+  cmakeFlags = [
+    "-DPYTHON_DESIRED=${lib.head (lib.splitString ["."] python.version)}"
+  ];
+
+  postBuild = ''
+    make doc-man
+  '';
+
+  postInstall = ''
+    # See https://github.com/rpm-software-management/dnf/blob/41a287e2bd60b4d1100c329a274776ff32ba8740/dnf.spec#L218-L220
+    ln -s dnf-3 $out/bin/dnf
+    ln -s dnf-3 $out/bin/dnf4
+    mv $out/bin/dnf-automatic-3 $out/bin/dnf-automatic
+    # See https://github.com/rpm-software-management/dnf/blob/41a287e2bd60b4d1100c329a274776ff32ba8740/dnf.spec#L231-L232
+    ln -s $out/etc/dnf/dnf.conf $out/etc/yum.conf
+    ln -s dnf-3 $out/bin/yum
+  '';
+
+  meta = with lib; {
+    description = "Package manager based on libdnf and libsolv. Replaces YUM";
+    homepage = "https://github.com/rpm-software-management/dnf";
+    changelog = "https://github.com/rpm-software-management/dnf/releases/tag/${version}";
+    license = licenses.gpl2Only;
+    maintainers = with maintainers; [ katexochen ];
+    mainProgram = "dnf";
+    platforms = platforms.unix;
+  };
+}
diff --git a/pkgs/development/python-modules/dnf4/fix-python-install-dir.patch b/pkgs/development/python-modules/dnf4/fix-python-install-dir.patch
new file mode 100644
index 000000000000..07b68242d8fc
--- /dev/null
+++ b/pkgs/development/python-modules/dnf4/fix-python-install-dir.patch
@@ -0,0 +1,13 @@
+diff --git a/CMakeLists.txt b/CMakeLists.txt
+index 4aee99fb..0bb28897 100644
+--- a/CMakeLists.txt
++++ b/CMakeLists.txt
+@@ -19,7 +19,7 @@ ELSE ()
+     MESSAGE (FATAL_ERROR "Invalid PYTHON_DESIRED value: " ${PYTHON_DESIRED})
+ ENDIF()
+
+-EXECUTE_PROCESS(COMMAND ${PYTHON_EXECUTABLE} -c "from sys import stdout; from sysconfig import get_path; stdout.write(get_path('purelib'))" OUTPUT_VARIABLE PYTHON_INSTALL_DIR)
++SET(PYTHON_INSTALL_DIR "@PYTHON_INSTALL_DIR@")
+ MESSAGE(STATUS "Python install dir is ${PYTHON_INSTALL_DIR}")
+
+ ADD_SUBDIRECTORY (dnf)
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index b78335bf26f4..65ab4c74cd0f 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -605,6 +605,8 @@ with pkgs;
 
   dec-decode = callPackage ../development/tools/dec-decode { };
 
+  dnf4 =  with python3Packages; toPythonApplication dnf4;
+
   dnf5 = callPackage ../tools/package-management/dnf5 { };
 
   documenso = callPackage ../applications/office/documenso { };
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index ab3462a2a171..a950a0ca5e52 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -3204,6 +3204,8 @@ self: super: with self; {
 
   dnachisel = callPackage ../development/python-modules/dnachisel { };
 
+  dnf4 = callPackage ../development/python-modules/dnf4 { };
+
   dnfile = callPackage ../development/python-modules/dnfile { };
 
   dnslib = callPackage ../development/python-modules/dnslib { };