diff --git a/pkgs/tools/graphics/vulkan-tools-lunarg/add-missing-macro-definition.patch b/pkgs/tools/graphics/vulkan-tools-lunarg/add-missing-macro-definition.patch
new file mode 100644
index 000000000000..4d5717363303
--- /dev/null
+++ b/pkgs/tools/graphics/vulkan-tools-lunarg/add-missing-macro-definition.patch
@@ -0,0 +1,26 @@
+diff --git a/layersvt/api_dump.h b/layersvt/api_dump.h
+index 6e13b6de3..33bee96e7 100644
+--- a/layersvt/api_dump.h
++++ b/layersvt/api_dump.h
+@@ -60,6 +60,8 @@
+ #include <unordered_set>
+ #include <utility>
+
++#define ARRAY_SIZE(a) (sizeof(a) / sizeof(a[0]))
++
+ #ifdef ANDROID
+
+ #include <android/log.h>
+diff --git a/layersvt/screenshot.cpp b/layersvt/screenshot.cpp
+index b9743371c..6ee65c576 100755
+--- a/layersvt/screenshot.cpp
++++ b/layersvt/screenshot.cpp
+@@ -44,6 +44,8 @@ using namespace std;
+
+ #include "screenshot_parsing.h"
+
++#define ARRAY_SIZE(a) (sizeof(a) / sizeof(a[0]))
++
+ #ifdef ANDROID
+
+ #include <android/log.h>
diff --git a/pkgs/tools/graphics/vulkan-tools-lunarg/default.nix b/pkgs/tools/graphics/vulkan-tools-lunarg/default.nix
index 88058d2caa3b..8dec2e5130e7 100644
--- a/pkgs/tools/graphics/vulkan-tools-lunarg/default.nix
+++ b/pkgs/tools/graphics/vulkan-tools-lunarg/default.nix
@@ -24,13 +24,13 @@
 
 stdenv.mkDerivation rec {
   pname = "vulkan-tools-lunarg";
-  version = "1.3.249";
+  version = "1.3.250";
 
   src = fetchFromGitHub {
    owner = "LunarG";
    repo = "VulkanTools";
    rev = "v${version}";
-   hash = "sha256-yQE6tjUxIZEMspxDaO9AoSjoEHQl2eDAc0E/aVQZnxQ=";
+   hash = "sha256-oI2ITvciuE/f8ojFpIwcH+HnYCasz43nKkER3wJxX+c=";
    fetchSubmodules = true;
  };
 
@@ -81,7 +81,17 @@ stdenv.mkDerivation rec {
     done
   '';
 
-  patches = [ ./gtest.patch ];
+  patches = [
+    # Redefine an internal macro removed in vulkan-validation-layers
+    # FIXME: remove when fixed upstream
+    ./add-missing-macro-definition.patch
+
+    # Skip QNX-specific extension causing build failures
+    # FIXME: remove when fixed upstream
+    ./skip-qnx-extension.patch
+
+    ./gtest.patch
+  ];
 
   # Same as vulkan-validation-layers
   dontPatchELF = true;
diff --git a/pkgs/tools/graphics/vulkan-tools-lunarg/skip-qnx-extension.patch b/pkgs/tools/graphics/vulkan-tools-lunarg/skip-qnx-extension.patch
new file mode 100644
index 000000000000..777b32f43af4
--- /dev/null
+++ b/pkgs/tools/graphics/vulkan-tools-lunarg/skip-qnx-extension.patch
@@ -0,0 +1,13 @@
+diff --git a/CMakeLists.txt b/CMakeLists.txt
+index 209f3ec39..c711af38b 100644
+--- a/CMakeLists.txt
++++ b/CMakeLists.txt
+@@ -190,7 +190,7 @@ endif()
+ # Define macro used for building vk.xml generated files
+ function(run_vulkantools_vk_xml_generate dependency output)
+     add_custom_command(OUTPUT ${output}
+-        COMMAND ${PYTHON_CMD} -B ${VULKANTOOLS_SCRIPTS_DIR}/vt_genvk.py -registry ${VULKAN_HEADERS_REGISTRY_DIRECTORY}/vk.xml -scripts ${VULKAN_HEADERS_REGISTRY_DIRECTORY} ${output}
++        COMMAND ${PYTHON_CMD} -B ${VULKANTOOLS_SCRIPTS_DIR}/vt_genvk.py -registry ${VULKAN_HEADERS_REGISTRY_DIRECTORY}/vk.xml -scripts ${VULKAN_HEADERS_REGISTRY_DIRECTORY} ${output} -removeExtensions VK_QNX_external_memory_screen_buffer
+         DEPENDS ${VULKAN_HEADERS_REGISTRY_DIRECTORY}/vk.xml ${VULKAN_HEADERS_REGISTRY_DIRECTORY}/generator.py ${VULKANTOOLS_SCRIPTS_DIR}/${dependency} ${VULKANTOOLS_SCRIPTS_DIR}/vt_genvk.py ${VULKAN_HEADERS_REGISTRY_DIRECTORY}/reg.py
+     )
+ endfunction()