diff --git a/pkgs/applications/science/math/wolfram-engine/default.nix b/pkgs/applications/science/math/wolfram-engine/default.nix
new file mode 100644
index 000000000000..df9e2f88dfca
--- /dev/null
+++ b/pkgs/applications/science/math/wolfram-engine/default.nix
@@ -0,0 +1,143 @@
+{ lib
+, stdenv
+, autoPatchelfHook
+, requireFile
+, callPackage
+, makeWrapper
+, alsa-lib
+, dbus
+, fontconfig
+, freetype
+, gcc
+, glib
+, installShellFiles
+, libssh2
+, ncurses
+, opencv4
+, openssl
+, unixODBC
+, xkeyboard_config
+, xorg
+, zlib
+, libxml2
+, libuuid
+, lang ? "en"
+, libGL
+, libGLU
+}:
+
+let
+  l10n = import ./l10ns.nix {
+    lib = lib;
+    inherit requireFile lang;
+  };
+  dirName = "WolframEngine";
+in
+stdenv.mkDerivation rec {
+  inherit (l10n) version name src;
+
+  nativeBuildInputs = [
+    autoPatchelfHook
+    installShellFiles
+    makeWrapper
+  ];
+
+  buildInputs = [
+    alsa-lib
+    dbus
+    fontconfig
+    freetype
+    gcc.cc
+    gcc.libc
+    glib
+    libssh2
+    ncurses
+    opencv4
+    openssl
+    stdenv.cc.cc.lib
+    unixODBC
+    xkeyboard_config
+    libxml2
+    libuuid
+    zlib
+    libGL
+    libGLU
+  ] ++ (with xorg; [
+    libX11
+    libXext
+    libXtst
+    libXi
+    libXmu
+    libXrender
+    libxcb
+    libXcursor
+    libXfixes
+    libXrandr
+    libICE
+    libSM
+  ]);
+
+  # some bundled libs are found through LD_LIBRARY_PATH
+  autoPatchelfIgnoreMissingDeps = true;
+
+  ldpath = lib.makeLibraryPath buildInputs
+    + lib.optionalString (stdenv.hostPlatform.system == "x86_64-linux")
+      (":" + lib.makeSearchPathOutput "lib" "lib64" buildInputs);
+
+  unpackPhase = ''
+    # find offset from file
+    offset=$(${stdenv.shell} -c "$(grep -axm1 -e 'offset=.*' $src); echo \$offset" $src)
+    dd if="$src" ibs=$offset skip=1 | tar -xf -
+    cd Unix
+  '';
+
+  installPhase = ''
+    cd Installer
+    sed -i -e 's/^PATH=/# PATH=/' -e 's/=`id -[ug]`/=0/' MathInstaller
+
+    # Installer wants to write default config in HOME
+    export HOME=$(mktemp -d)
+
+    # Fix the installation script
+    patchShebangs MathInstaller
+    substituteInPlace MathInstaller \
+      --replace "`hostname`" "" \
+      --replace "chgrp" "# chgrp" \
+      --replace "chown" ": # chown"
+
+    # Install the desktop items
+    export XDG_DATA_HOME="$out/share"
+
+    ./MathInstaller -auto -createdir=y -execdir=$out/bin -targetdir=$out/libexec/${dirName} -silent
+
+    # Fix library paths
+    cd $out/libexec/${dirName}/Executables
+    for path in MathKernel WolframKernel math mcc wolfram; do
+      makeWrapper $out/libexec/${dirName}/Executables/$path $out/bin/$path --set LD_LIBRARY_PATH "${zlib}/lib:${stdenv.cc.cc.lib}/lib:${libssh2}/lib:\''${LD_LIBRARY_PATH}"
+    done
+
+    # ... and xkeyboard config path for Qt
+    for path in WolframPlayer wolframplayer; do
+      makeWrapper $out/libexec/${dirName}/Executables/$path $out/bin/$path \
+        --set LD_LIBRARY_PATH "${zlib}/lib:${stdenv.cc.cc.lib}/lib:${libssh2}/lib:\''${LD_LIBRARY_PATH}" \
+        --set QT_XKB_CONFIG_ROOT "${xkeyboard_config}/share/X11/xkb"
+    done
+
+    # Install man pages
+    installManPage $out/libexec/${dirName}/SystemFiles/SystemDocumentation/Unix/*
+  '';
+
+  # This is primarily an IO bound build; there's little benefit to building remotely.
+  preferLocalBuild = true;
+
+  # Stripping causes the program to core dump.
+  dontStrip = true;
+
+  meta = with lib; {
+    description = "Wolfram Engine computational software system";
+    homepage = "https://www.wolfram.com/engine/";
+    license = licenses.unfree;
+    maintainers = with maintainers; [ fbeffa ];
+    platforms = [ "x86_64-linux" ];
+  };
+}
diff --git a/pkgs/applications/science/math/wolfram-engine/l10ns.nix b/pkgs/applications/science/math/wolfram-engine/l10ns.nix
new file mode 100644
index 000000000000..9bee8052c6e3
--- /dev/null
+++ b/pkgs/applications/science/math/wolfram-engine/l10ns.nix
@@ -0,0 +1,51 @@
+{ lib
+, requireFile
+, lang
+, majorVersion ? null
+}:
+
+let allVersions = with lib; flip map
+  # N.B. Versions in this list should be ordered from newest to oldest.
+  [
+    {
+      version = "13.0.1";
+      lang = "en";
+      language = "English";
+      sha256 = "1rrxi7d51m02407k719fq829jzanh550wr810i22n3irhk8axqga";
+      installer = "WolframEngine_13.0.1_LINUX.sh";
+    }
+    {
+      version = "13.0.0";
+      lang = "en";
+      language = "English";
+      sha256 = "10cpwllz9plxz22iqdh6xgkxqphl9s9nq8ax16pafjll6j9kqy1q";
+      installer = "WolframEngine_13.0.0_LINUX.sh";
+    }
+  ]
+  ({ version, lang, language, sha256, installer }: {
+    inherit version lang;
+    name = "wolfram-engine-${version}" + optionalString (lang != "en") "-${lang}";
+    src = requireFile {
+      name = installer;
+      message = ''
+        This nix expression requires that ${installer} is
+        already part of the store. Download the file from
+        https://www.wolfram.com/engine/ and add it to the nix store
+        with nix-store --add-fixed sha256 <FILE>.
+      '';
+      inherit sha256;
+    };
+  });
+minVersion =
+  with lib;
+  if majorVersion == null
+  then elemAt (builtins.splitVersion (elemAt allVersions 0).version) 0
+  else majorVersion;
+maxVersion = toString (1 + builtins.fromJSON minVersion);
+in
+with lib;
+findFirst (l: (l.lang == lang
+               && l.version >= minVersion
+               && l.version < maxVersion))
+          (throw "Version ${minVersion} in language ${lang} not supported")
+          allVersions
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index dedabba0e5a8..ff933dd1867a 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -32635,6 +32635,8 @@ with pkgs;
 
   trilinos-mpi = callPackage ../development/libraries/science/math/trilinos { withMPI = true; };
 
+  wolfram-engine = callPackage ../applications/science/math/wolfram-engine { };
+
   ipopt = callPackage ../development/libraries/science/math/ipopt { };
 
   gmsh = callPackage ../applications/science/math/gmsh { };