diff --git a/pkgs/development/python-modules/HTSeq/default.nix b/pkgs/development/python-modules/htseq/default.nix
similarity index 97%
rename from pkgs/development/python-modules/HTSeq/default.nix
rename to pkgs/development/python-modules/htseq/default.nix
index 486f8a4556f5..5c369d7f06a8 100644
--- a/pkgs/development/python-modules/HTSeq/default.nix
+++ b/pkgs/development/python-modules/htseq/default.nix
@@ -1,7 +1,7 @@
 { lib, buildPythonPackage, fetchFromGitHub, cython, numpy, pysam, matplotlib, python, isPy27, isPy3k }:
 buildPythonPackage rec {
   version = "0.12.4";
-  pname = "HTSeq";
+  pname = "htseq";
 
   src = fetchFromGitHub {
     owner = "htseq";
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 3fa645de155b..b1c6a049c516 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -115,6 +115,7 @@ mapAliases ({
   hangups = throw "hangups was removed because Google Hangouts has been shut down"; # added 2023-02-13
   hbmqtt = throw "hbmqtt was removed because it is no longer maintained"; # added 2021-11-07
   hdlparse = throw "hdlparse has been removed, it was using setuptools 2to3 translation feature, which has been removed in setuptools 58"; # added 2022-01-18
+  HTSeq = htseq; # added 2023-02-19
   hyperkitty = throw "Please use pkgs.mailmanPackages.hyperkitty"; # added 2022-04-29
   IMAPClient = imapclient; # added 2021-10-28
   imdbpy = throw "imdbpy has been renamed to cinemagoer"; # added 2022-08-08
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 7771d78fdc6b..fcf226fb1e42 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -4420,7 +4420,7 @@ self: super: with self; {
 
   html-text = callPackage ../development/python-modules/html-text { };
 
-  HTSeq = callPackage ../development/python-modules/HTSeq { };
+  htseq = callPackage ../development/python-modules/htseq { };
 
   httmock = callPackage ../development/python-modules/httmock { };