diff --git a/doc/stdenv/stdenv.chapter.md b/doc/stdenv/stdenv.chapter.md
index 7019ae89db74..40f295b178bb 100644
--- a/doc/stdenv/stdenv.chapter.md
+++ b/doc/stdenv/stdenv.chapter.md
@@ -1043,7 +1043,7 @@ You can also specify a `runtimeDependencies` variable which lists dependencies t
 
 In certain situations you may want to run the main command (`autoPatchelf`) of the setup hook on a file or a set of directories instead of unconditionally patching all outputs. This can be done by setting the `dontAutoPatchelf` environment variable to a non-empty value.
 
-By default `autoPatchelf` will fail as soon as any ELF file requires a dependency which cannot be resolved via the given build inputs. In some situations you might prefer to just leave missing dependencies unpatched and continue to patch the rest. This can be achieved by setting the `autoPatchelfIgnoreMissingDeps` environment variable to a non-empty value.
+By default `autoPatchelf` will fail as soon as any ELF file requires a dependency which cannot be resolved via the given build inputs. In some situations you might prefer to just leave missing dependencies unpatched and continue to patch the rest. This can be achieved by setting the `autoPatchelfIgnoreMissingDeps` environment variable to a non-empty value. `autoPatchelfIgnoreMissingDeps` can be set to a list like `autoPatchelfIgnoreMissingDeps = [ "libcuda.so.1" "libcudart.so.1" ];` or to simply `[ "*" ]` to ignore all missing dependencies.
 
 The `autoPatchelf` command also recognizes a `--no-recurse` command line flag, which prevents it from recursing into subdirectories.
 
diff --git a/pkgs/build-support/setup-hooks/auto-patchelf.py b/pkgs/build-support/setup-hooks/auto-patchelf.py
index 26fd623e3da0..861d772698d0 100644
--- a/pkgs/build-support/setup-hooks/auto-patchelf.py
+++ b/pkgs/build-support/setup-hooks/auto-patchelf.py
@@ -1,23 +1,21 @@
 #!/usr/bin/env python3
 
-from collections import defaultdict
-from contextlib import contextmanager
-from dataclasses import dataclass
-from elftools.common.exceptions import ELFError # type: ignore
-from elftools.elf.dynamic import DynamicSection # type: ignore
-from elftools.elf.elffile import ELFFile # type: ignore
-from elftools.elf.enums import ENUM_E_TYPE, ENUM_EI_OSABI # type: ignore
-from itertools import chain
-from pathlib import Path, PurePath
-
-from typing import Tuple, Optional, Iterator, List, DefaultDict, Set
-
 import argparse
 import os
 import pprint
 import subprocess
 import sys
+from collections import defaultdict
+from contextlib import contextmanager
+from dataclasses import dataclass
+from itertools import chain
+from pathlib import Path, PurePath
+from typing import DefaultDict, Iterator, List, Optional, Set, Tuple
 
+from elftools.common.exceptions import ELFError  # type: ignore
+from elftools.elf.dynamic import DynamicSection  # type: ignore
+from elftools.elf.elffile import ELFFile  # type: ignore
+from elftools.elf.enums import ENUM_E_TYPE, ENUM_EI_OSABI  # type: ignore
 
 
 @contextmanager
@@ -246,7 +244,7 @@ def auto_patchelf(
         lib_dirs: List[Path],
         runtime_deps: List[Path],
         recursive: bool =True,
-        ignore_missing: bool =False) -> None:
+        ignore_missing: List[str] = []) -> None:
 
     if not paths_to_patch:
         sys.exit("No paths to patch, stopping.")
@@ -264,12 +262,19 @@ def auto_patchelf(
     missing = [dep for dep in dependencies if not dep.found]
 
     # Print a summary of the missing dependencies at the end
+    print(f"auto-patchelf: {len(missing)} dependencies could not be satisfied")
+    failure = False
     for dep in missing:
-        print(f"auto-patchelf could not satisfy dependency {dep.name} wanted by {dep.file}")
+        if dep.name.name in ignore_missing or "*" in ignore_missing:
+            print(f"warn: auto-patchelf ignoring missing {dep.name} wanted by {dep.file}")
+        else:
+            print(f"error: auto-patchelf could not satisfy dependency {dep.name} wanted by {dep.file}")
+            failure = True
 
-    if missing and not ignore_missing:
+    if failure:
         sys.exit('auto-patchelf failed to find all the required dependencies.\n'
-                 'Add the missing dependencies to --libs or use --ignore-missing.')
+                 'Add the missing dependencies to --libs or use '
+                 '`--ignore-missing="foo.so.1 bar.so etc.so"`.')
 
 
 def main() -> None:
@@ -280,7 +285,8 @@ def main() -> None:
                     'libraries in the provided paths.')
     parser.add_argument(
         "--ignore-missing",
-        action="store_true",
+        nargs="*",
+        type=str,
         help="Do not fail when some dependencies are not found.")
     parser.add_argument(
         "--no-recurse",
diff --git a/pkgs/build-support/setup-hooks/auto-patchelf.sh b/pkgs/build-support/setup-hooks/auto-patchelf.sh
index 9822674196ae..661b8597efea 100644
--- a/pkgs/build-support/setup-hooks/auto-patchelf.sh
+++ b/pkgs/build-support/setup-hooks/auto-patchelf.sh
@@ -53,10 +53,17 @@ autoPatchelf() {
         esac
     done
 
+    if [ "${autoPatchelfIgnoreMissingDeps[*]}" == "1" ]; then
+        echo "autoPatchelf: WARNING: setting 'autoPatchelfIgnoreMissingDeps" \
+             "= true;' is deprecated and will be removed in a future release." \
+             "Use 'autoPatchelfIgnoreMissingDeps = [ \"*\" ];' instead." >&2
+        autoPatchelfIgnoreMissingDeps=( "*" )
+    fi
+
     local runtimeDependenciesArray=($runtimeDependencies)
     @pythonInterpreter@ @autoPatchelfScript@                            \
         ${norecurse:+--no-recurse}                                      \
-        ${autoPatchelfIgnoreMissingDeps:+--ignore-missing}              \
+        --ignore-missing "${autoPatchelfIgnoreMissingDeps[@]}"          \
         --paths "$@"                                                    \
         --libs "${autoPatchelfLibs[@]}"                                 \
                "${extraAutoPatchelfLibs[@]}"                            \
diff --git a/pkgs/development/libraries/openvino/default.nix b/pkgs/development/libraries/openvino/default.nix
index 86bc3b0d009c..6e253b973180 100644
--- a/pkgs/development/libraries/openvino/default.nix
+++ b/pkgs/development/libraries/openvino/default.nix
@@ -90,7 +90,7 @@ stdenv.mkDerivation rec {
     cd ../build
   '';
 
-  autoPatchelfIgnoreMissingDeps = true;
+  autoPatchelfIgnoreMissingDeps = [ "libngraph_backend.so" ];
 
   nativeBuildInputs = [
     cmake
diff --git a/pkgs/tools/games/opentracker/default.nix b/pkgs/tools/games/opentracker/default.nix
index 6386d5daaf0e..c6e3987b81c8 100644
--- a/pkgs/tools/games/opentracker/default.nix
+++ b/pkgs/tools/games/opentracker/default.nix
@@ -52,7 +52,7 @@ buildDotnetModule rec {
     xinput
   ];
 
-  autoPatchelfIgnoreMissingDeps = true; # Attempts to patchelf unneeded SOs
+  autoPatchelfIgnoreMissingDeps = [ "libc.musl-x86_64.so.1" ]; # Attempts to patchelf unneeded SOs
 
   meta = with lib; {
     description = "A tracking application for A Link to the Past Randomizer";