diff --git a/pkgs/development/python-modules/scikit-survival/default.nix b/pkgs/development/python-modules/scikit-survival/default.nix
index b2c4218e5f33..9a766cedece3 100644
--- a/pkgs/development/python-modules/scikit-survival/default.nix
+++ b/pkgs/development/python-modules/scikit-survival/default.nix
@@ -17,12 +17,12 @@
 
 buildPythonPackage rec {
   pname = "scikit-survival";
-  version = "0.21.0";
-  format = "setuptools";
+  version = "0.22.1";
+  pyproject = true;
 
   src = fetchPypi {
     inherit pname version;
-    hash = "sha256-rcdEtlmD3O2BQuwxRlOJ/HOEBdWJBRJR5UR6rZoeArw=";
+    hash = "sha256-Ft0Hg5iF9Sb9VSOsFMgfAvc4Nsam216kzt5Xv2iykv8=";
   };
 
   nativeBuildInputs = [
@@ -45,6 +45,11 @@ buildPythonPackage rec {
 
   nativeCheckInputs = [ pytestCheckHook ];
 
+  # treat numpy versions as lower bounds, same as setuptools build
+  postPatch = ''
+    sed -i 's/numpy==/numpy>=/' pyproject.toml
+  '';
+
   # Hack needed to make pytest + cython work
   # https://github.com/NixOS/nixpkgs/pull/82410#issuecomment-827186298
   preCheck = ''
@@ -63,10 +68,13 @@ buildPythonPackage rec {
     "test_pandas_inputs"
     "test_survival_svm"
     "test_tree"
-  ];
+  ] ++ lib.optional (stdenv.isDarwin && stdenv.isAarch64)
+    # floating point mismatch on aarch64
+    # 27079905.88052468 to far from 27079905.880496684
+    "test_coxnet"
+  ;
 
   meta = with lib; {
-    broken = (stdenv.isLinux && stdenv.isAarch64);
     description = "Survival analysis built on top of scikit-learn";
     homepage = "https://github.com/sebp/scikit-survival";
     license = licenses.gpl3Only;