diff --git a/pkgs/development/ocaml-modules/cstruct/ppx.nix b/pkgs/development/ocaml-modules/cstruct/ppx.nix
index 96814ebdc72a..1cae0cc3dea4 100644
--- a/pkgs/development/ocaml-modules/cstruct/ppx.nix
+++ b/pkgs/development/ocaml-modules/cstruct/ppx.nix
@@ -1,4 +1,4 @@
-{ lib, buildDunePackage, cstruct, sexplib, ppxlib
+{ lib, buildDunePackage, ocaml, cstruct, sexplib, ppxlib
 , ocaml-migrate-parsetree-2
 , ounit, cppo, ppx_sexp_conv, cstruct-unix, cstruct-sexp
 }:
@@ -15,7 +15,7 @@ else
 
     propagatedBuildInputs = [ cstruct ppxlib sexplib ];
 
-    doCheck = true;
+    doCheck = !lib.versionAtLeast ocaml.version "5.1";
     nativeCheckInputs = [ cppo ];
     checkInputs = [ ounit ppx_sexp_conv cstruct-sexp cstruct-unix ocaml-migrate-parsetree-2 ];
   }