diff --git a/pkgs/development/python-modules/pipx/default.nix b/pkgs/development/python-modules/pipx/default.nix
new file mode 100644
index 000000000000..e39c791d9c46
--- /dev/null
+++ b/pkgs/development/python-modules/pipx/default.nix
@@ -0,0 +1,59 @@
+{ lib
+, buildPythonPackage
+, fetchFromGitHub
+, pythonOlder
+, userpath
+, argcomplete
+, packaging
+, pytestCheckHook
+}:
+
+buildPythonPackage rec {
+  pname = "pipx";
+  version = "0.15.5.0";
+
+  disabled = pythonOlder "3.6";
+
+  # no tests in the pypi tarball, so we directly fetch from github
+  src = fetchFromGitHub {
+    owner = "pipxproject";
+    repo = pname;
+    rev = version;
+    sha256 = "13z032i8r9f6d09hssvyjpxjacb4wgms5bh2i37da2ili9bh72m6";
+  };
+
+  propagatedBuildInputs = [ userpath argcomplete packaging ];
+
+  # avoid inconclusive venv assertion, see https://github.com/pipxproject/pipx/pull/477
+  # remove after PR is merged
+  postPatch = ''
+    substituteInPlace tests/helpers.py \
+      --replace 'assert getattr(sys, "base_prefix", sys.prefix) != sys.prefix, "Tests require venv"' ""
+  '';
+
+  checkInputs = [ pytestCheckHook ];
+
+  preCheck = ''
+    export HOME=$(mktemp -d)
+  '';
+
+  # disable tests, which require internet connection
+  disabledTests = [
+    "install"
+    "inject"
+    "ensure_null_pythonpath"
+    "missing_interpreter"
+    "cache"
+    "internet"
+    "runpip"
+    "upgrade"
+  ];
+
+  meta = with lib; {
+    description =
+      "Install and Run Python Applications in Isolated Environments";
+    homepage = "https://github.com/pipxproject/pipx";
+    license = licenses.mit;
+    maintainers = with maintainers; [ yevhenshymotiuk ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index bde2da684f82..57bf95b4606a 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -5346,6 +5346,8 @@ in {
 
   pip = callPackage ../development/python-modules/pip { };
 
+  pipx = callPackage ../development/python-modules/pipx { };
+
   pip-tools = callPackage ../development/python-modules/pip-tools {
     git = pkgs.gitMinimal;
     glibcLocales = pkgs.glibcLocales;