diff --git a/doc/languages-frameworks/python.section.md b/doc/languages-frameworks/python.section.md
index 9250961f581c..da06fe1d69b5 100644
--- a/doc/languages-frameworks/python.section.md
+++ b/doc/languages-frameworks/python.section.md
@@ -116,7 +116,7 @@ buildPythonPackage rec {
     rm testing/test_argcomplete.py
   '';
 
-  nativeBuildInputs = [
+  build-system = [
     setuptools-scm
   ];
 
@@ -172,7 +172,7 @@ following are specific to `buildPythonPackage`:
   variable in wrapped programs.
 * `pyproject`: Whether the pyproject format should be used. When set to `true`,
   `pypaBuildHook` will be used, and you can add the required build dependencies
-  from `build-system.requires` to `nativeBuildInputs`. Note that the pyproject
+  from `build-system.requires` to `build-system`. Note that the pyproject
   format falls back to using `setuptools`, so you can use `pyproject = true`
   even if the package only has a `setup.py`. When set to `false`, you can
   use the existing [hooks](#setup-hooks0 or provide your own logic to build the
@@ -206,8 +206,8 @@ build inputs (see "Specifying dependencies"). The following are of special
 interest for Python packages, either because these are primarily used, or
 because their behaviour is different:
 
-* `nativeBuildInputs ? []`: Build-time only dependencies. Typically executables
-  as well as the items listed in `setup_requires`.
+* `nativeBuildInputs ? []`: Build-time only dependencies. Typically executables.
+* `build-system ? []`: Build-time only Python dependencies. Items listed in `build-system.requires`/`setup_requires`.
 * `buildInputs ? []`: Build and/or run-time dependencies that need to be
   compiled for the host machine. Typically non-Python libraries which are being
   linked.
@@ -304,13 +304,14 @@ python3Packages.buildPythonApplication rec {
     hash  = "sha256-Pe229rT0aHwA98s+nTHQMEFKZPo/yw6sot8MivFDvAw=";
   };
 
-  nativeBuildInputs = with python3Packages; [
+  build-system = with python3Packages; [
     setuptools
+    wheel
   ];
 
-  dependencies = [
-    python3Packages.tornado
-    python3Packages.python-daemon
+  dependencies = with python3Packages; [
+    tornado
+    python-daemon
   ];
 
   meta = with lib; {
@@ -467,11 +468,11 @@ are used in [`buildPythonPackage`](#buildpythonpackage-function).
 - `eggBuildHook` to skip building for eggs.
 - `eggInstallHook` to install eggs.
 - `pipBuildHook` to build a wheel using `pip` and PEP 517. Note a build system
-  (e.g. `setuptools` or `flit`) should still be added as `nativeBuildInput`.
+  (e.g. `setuptools` or `flit`) should still be added as `build-system`.
 - `pypaBuildHook` to build a wheel using
   [`pypa/build`](https://pypa-build.readthedocs.io/en/latest/index.html) and
   PEP 517/518. Note a build system (e.g. `setuptools` or `flit`) should still
-  be added as `nativeBuildInput`.
+  be added as `build-system`.
 - `pipInstallHook` to install wheels.
 - `pytestCheckHook` to run tests with `pytest`. See [example usage](#using-pytestcheckhook).
 - `pythonCatchConflictsHook` to check whether a Python package is not already existing.
@@ -886,7 +887,7 @@ buildPythonPackage rec {
     hash = "sha256-CP3V73yWSArRHBLUct4hrNMjWZlvaaUlkpm1QP66RWA=";
   };
 
-  nativeBuildInputs = [
+  build-system = [
     setuptools
     wheel
   ];
@@ -946,7 +947,7 @@ with import <nixpkgs> {};
         hash = "sha256-CP3V73yWSArRHBLUct4hrNMjWZlvaaUlkpm1QP66RWA=";
       };
 
-      nativeBuildInputs = [
+      build-system = [
         python311.pkgs.setuptools
         python311.pkgs.wheel
       ];
@@ -1020,7 +1021,7 @@ buildPythonPackage rec {
     hash = "sha256-FLLvdm1MllKrgTGC6Gb0k0deZeVYvtCCLji/B7uhong=";
   };
 
-  nativeBuildInputs = [
+  build-system = [
     setuptools
     wheel
   ];
@@ -1075,7 +1076,7 @@ buildPythonPackage rec {
     hash = "sha256-s9NiusRxFydHzaNRMjjxFcvWxfi45jGb9ql6eJJyQJk=";
   };
 
-  nativeBuildInputs = [
+  build-system = [
     setuptools
     wheel
   ];
@@ -1132,7 +1133,7 @@ buildPythonPackage rec {
     hash = "sha256-9ru2r6kwhUCaskiFoaPNuJCfCVoUL01J40byvRt4kHQ=";
   };
 
-  nativeBuildInputs = [
+  build-system = [
     setuptools
     wheel
   ];
@@ -1526,7 +1527,7 @@ buildPythonPackage rec {
     hash = "sha256-CP3V73yWSArRHBLUct4hrNMjWZlvaaUlkpm1QP66RWA=";
   };
 
-  nativeBuildInputs = [
+  build-system = [
     setuptools
     wheel
   ];
diff --git a/pkgs/development/interpreters/python/mk-python-derivation.nix b/pkgs/development/interpreters/python/mk-python-derivation.nix
index d06c2e3099ae..074ccbf1bd23 100644
--- a/pkgs/development/interpreters/python/mk-python-derivation.nix
+++ b/pkgs/development/interpreters/python/mk-python-derivation.nix
@@ -50,6 +50,9 @@
 , dependencies ? []
 , optional-dependencies ? {}
 
+# Python PEP-517 build systems.
+, build-system ? []
+
 # DEPRECATED: use propagatedBuildInputs
 , pythonPath ? []
 
@@ -208,13 +211,16 @@ let
     }
     // lib.optionalAttrs (optional-dependencies != {}) {
       inherit optional-dependencies;
+    }
+    // lib.optionalAttrs (build-system != []) {
+      inherit build-system;
     };
 
   # Keep extra attributes from `attrs`, e.g., `patchPhase', etc.
   self = toPythonModule (stdenv.mkDerivation ((builtins.removeAttrs attrs [
     "disabled" "checkPhase" "checkInputs" "nativeCheckInputs" "doCheck" "doInstallCheck" "dontWrapPythonPrograms" "catchConflicts" "pyproject" "format"
     "disabledTestPaths" "outputs" "stdenv"
-    "dependencies" "optional-dependencies"
+    "dependencies" "optional-dependencies" "build-system"
   ]) // {
 
     name = namePrefix + name_;
@@ -274,7 +280,7 @@ let
       pythonNamespacesHook
     ] ++ lib.optionals withDistOutput [
       pythonOutputDistHook
-    ] ++ nativeBuildInputs;
+    ] ++ nativeBuildInputs ++ build-system;
 
     buildInputs = validatePythonMatches "buildInputs" (buildInputs ++ pythonPath);