diff --git a/pkgs/games/openxray/default.nix b/pkgs/games/openxray/default.nix
index fde0e2eedf9c..8751de6835fb 100644
--- a/pkgs/games/openxray/default.nix
+++ b/pkgs/games/openxray/default.nix
@@ -51,10 +51,18 @@ stdenv.mkDerivation (finalAttrs: {
   cmakeBuildType = "RelWithDebInfo";
   dontStrip = true;
 
+  makeWrapperArgs = lib.optionals stdenv.hostPlatform.isLinux [
+    # Needed because of dlopen module loading code
+    "--prefix LD_LIBRARY_PATH : $out/lib"
+  ] ++ lib.optionals stdenv.hostPlatform.isDarwin [
+    # Because we work around https://github.com/OpenXRay/xray-16/issues/1224 by using GCC,
+    # we need a followup workaround for Darwin locale stuff when using GCC:
+    # runtime error: locale::facet::_S_create_c_locale name not valid
+    "--run 'export LC_ALL=C'"
+  ];
+
   postInstall = ''
-    # needed because of SDL_LoadObject library loading code
-    wrapProgram $out/bin/xr_3da \
-      --prefix LD_LIBRARY_PATH : $out/lib
+    wrapProgram $out/bin/xr_3da ${toString finalAttrs.makeWrapperArgs}
   '';
 
   meta = with lib; {
@@ -65,6 +73,6 @@ stdenv.mkDerivation (finalAttrs: {
       url = "https://github.com/OpenXRay/xray-16/blob/${version}/License.txt";
     };
     maintainers = with maintainers; [ OPNA2608 ];
-    platforms = [ "x86_64-linux" "i686-linux" "aarch64-linux" ];
+    platforms = [ "x86_64-linux" "i686-linux" "aarch64-linux" "x86_64-darwin" "aarch64-darwin" ];
   };
 })
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index dadc9464cea4..e14edb5f543f 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -38074,7 +38074,11 @@ with pkgs;
 
   openxcom = callPackage ../games/openxcom { SDL = SDL_compat; };
 
-  openxray = callPackage ../games/openxray { };
+  openxray = callPackage ../games/openxray {
+    # Builds with Clang, but hits an assertion failure unless GCC is used
+    # https://github.com/OpenXRay/xray-16/issues/1224
+    stdenv = gccStdenv;
+  };
 
   orthorobot = callPackage ../games/orthorobot { love = love_0_10; };