diff --git a/pkgs/development/python-modules/python-prctl/default.nix b/pkgs/development/python-modules/python-prctl/default.nix
index 2fd88858de75..dc967b54305c 100644
--- a/pkgs/development/python-modules/python-prctl/default.nix
+++ b/pkgs/development/python-modules/python-prctl/default.nix
@@ -2,6 +2,7 @@
 , buildPythonPackage
 , fetchPypi
 , libcap
+, pytestCheckHook
 }:
 
 buildPythonPackage rec {
@@ -13,9 +14,25 @@ buildPythonPackage rec {
     sha256 = "b4ca9a25a7d4f1ace4fffd1f3a2e64ef5208fe05f929f3edd5e27081ca7e67ce";
   };
 
-  patches = [ ./skip_bad_tests.patch ];
   buildInputs = [ libcap ];
 
+  checkInputs = [ pytestCheckHook ];
+
+  disabledTests = [
+    # Intel MPX support was removed in GCC 9.1 & Linux kernel 5.6
+    "test_mpx"
+
+    # The Nix build sandbox has no_new_privs already enabled
+    "test_no_new_privs"
+
+    # The Nix build sandbox has seccomp already enabled
+    "test_seccomp"
+
+    # This will fail if prctl(PR_SET_SPECULATION_CTRL, PR_SPEC_FORCE_DISABLE)
+    # has been set system-wide, even outside the sandbox
+    "test_speculation_ctrl"
+  ];
+
   meta = {
     description = "Python(ic) interface to the linux prctl syscall";
     homepage = "https://github.com/seveas/python-prctl";
diff --git a/pkgs/development/python-modules/python-prctl/skip_bad_tests.patch b/pkgs/development/python-modules/python-prctl/skip_bad_tests.patch
deleted file mode 100644
index 19d70f234a99..000000000000
--- a/pkgs/development/python-modules/python-prctl/skip_bad_tests.patch
+++ /dev/null
@@ -1,34 +0,0 @@
---- ./test_prctl.py	2018-01-26 16:02:52.000000000 -0500
-+++ ./test_prctl.py	2018-06-21 18:26:43.370065009 -0400
-@@ -154,6 +154,7 @@
-         prctl.set_keepcaps(False)
-         self.assertEqual(prctl.get_keepcaps(), False)
- 
-+    @unittest.skip("No access to /proc in the Nix build sandbox")
-     @require('set_mce_kill')
-     def test_mce_kill(self):
-         """Test the MCE_KILL setting"""
-@@ -173,6 +174,7 @@
-         prctl.set_name(name)
-         self.assertEqual(prctl.get_name(), name[:15])
- 
-+    @unittest.skip("The Nix build sandbox has no_new_privs already enabled")
-     @require('get_no_new_privs')
-     def test_no_new_privs(self):
-         """Test the no_new_privs function"""
-@@ -189,6 +191,7 @@
-                 self.assertNotEqual(sp.returncode, 0)
-             os._exit(0)
- 
-+    @unittest.skip("No access to /proc in the Nix build sandbox")
-     def test_proctitle(self):
-         """Test setting the process title, including too long titles"""
-         title = "This is a test!"
-@@ -225,6 +228,7 @@
-             os._exit(0)
-         self.assertRaises(OSError, prctl.set_ptracer, new_pid)
- 
-+    @unittest.skip("The Nix build sandbox has seccomp already enabled")
-     @require('get_seccomp')
-     def test_seccomp(self):
-         """Test manipulation of the seccomp setting"""