diff --git a/pkgs/applications/misc/loxodo/default.nix b/pkgs/applications/misc/loxodo/default.nix
index bcfd581edcf9..53ea7730cb12 100644
--- a/pkgs/applications/misc/loxodo/default.nix
+++ b/pkgs/applications/misc/loxodo/default.nix
@@ -11,7 +11,9 @@ python3.pkgs.buildPythonApplication {
     sha256 = "1cips4pvrqga8q1ibs23vjrf8dwan860x8jvjmc52h6qvvvv60yl";
   };
 
-  propagatedBuildInputs = with python3.pkgs; [ six wxPython_4_0 ];
+  patches = [ ./wxpython.patch ];
+
+  propagatedBuildInputs = with python3.pkgs; [ six wxPython_4_2 ];
 
   postInstall = ''
     mv $out/bin/loxodo.py $out/bin/loxodo
diff --git a/pkgs/applications/misc/loxodo/wxpython.patch b/pkgs/applications/misc/loxodo/wxpython.patch
new file mode 100644
index 000000000000..e22d3b5ad708
--- /dev/null
+++ b/pkgs/applications/misc/loxodo/wxpython.patch
@@ -0,0 +1,25 @@
+diff --git a/loxodo.py b/loxodo.py
+index 68ad4c8..e96bc1a 100755
+--- a/loxodo.py
++++ b/loxodo.py
+@@ -41,7 +41,7 @@ if len(sys.argv) > 1:
+ # In all other cases, use the "wx" frontend.
+ try:
+     import wx
+-    assert(wx.__version__.startswith('4.0.'))
++    assert(wx.__version__.startswith('4.'))
+ except AssertionError as e:
+     print('Found incompatible wxPython, the wxWidgets Python bindings: %s' % wx.__version__, file=sys.stderr)
+     print('Falling back to cmdline frontend.', file=sys.stderr)
+diff --git a/src/frontends/wx/loxodo.py b/src/frontends/wx/loxodo.py
+index bc3f509..e02c4bf 100644
+--- a/src/frontends/wx/loxodo.py
++++ b/src/frontends/wx/loxodo.py
+@@ -25,6 +25,7 @@ from .loadframe import LoadFrame
+ 
+ 
+ def main():
++    wx.SizerFlags.DisableConsistencyChecks()
+     app = wx.App(False)
+     setup_wx_locale()
+     mainframe = LoadFrame(None, -1, "")