diff --git a/pkgs/tools/networking/unbound/default.nix b/pkgs/tools/networking/unbound/default.nix
index a0c774fb7341..2e31fadba377 100644
--- a/pkgs/tools/networking/unbound/default.nix
+++ b/pkgs/tools/networking/unbound/default.nix
@@ -59,6 +59,13 @@ stdenv.mkDerivation rec {
     "--with-libnghttp2=${libnghttp2.dev}"
   ];
 
+  # Remove references to compile-time dependencies that are included in the configure flags
+  postConfigure = let
+    inherit (builtins) storeDir;
+  in ''
+    sed -E '/CONFCMDLINE/ s;${storeDir}/[a-z0-9]{32}-;${storeDir}/eeeeeeeeeeeeeeeeeeeeeeeeeeeeeeee-;g' -i config.h
+  '';
+
   installFlags = [ "configfile=\${out}/etc/unbound/unbound.conf" ];
 
   postInstall = ''