diff --git a/pkgs/development/python-modules/guestfs/default.nix b/pkgs/development/python-modules/guestfs/default.nix
index 0f1d2ddf05cc..68401e9ea4d9 100644
--- a/pkgs/development/python-modules/guestfs/default.nix
+++ b/pkgs/development/python-modules/guestfs/default.nix
@@ -20,5 +20,6 @@ buildPythonPackage rec {
     description = "Use libguestfs from Python";
     license = licenses.lgpl2Plus;
     maintainers = with maintainers; [ grahamc ];
+    inherit (libguestfs.meta) platforms;
   };
 }
diff --git a/pkgs/development/python-modules/pyxattr/default.nix b/pkgs/development/python-modules/pyxattr/default.nix
index 7e1676dafa63..2bc4a9bf950e 100644
--- a/pkgs/development/python-modules/pyxattr/default.nix
+++ b/pkgs/development/python-modules/pyxattr/default.nix
@@ -21,5 +21,6 @@ buildPythonPackage rec {
     meta = with lib; {
       description = "A Python extension module which gives access to the extended attributes for filesystem objects available in some operating systems";
       license = licenses.lgpl21Plus;
+      inherit (pkgs.attr.meta) platforms;
     };
 }
diff --git a/pkgs/tools/misc/diffoscope/default.nix b/pkgs/tools/misc/diffoscope/default.nix
index 6e9a057af077..9f1b76badbba 100644
--- a/pkgs/tools/misc/diffoscope/default.nix
+++ b/pkgs/tools/misc/diffoscope/default.nix
@@ -3,7 +3,8 @@
 , e2fsprogs, enjarify, file, findutils, fontforge-fonttools, ffmpeg, fpc, gettext, ghc, ghostscriptX, giflib, gnumeric, gnupg, gnutar
 , gzip, html2text, hdf5, imagemagick, jdk, libarchive, libcaca, llvm, lz4, mono, ocaml, oggvideotools, openssh, openssl, pdftk, pgpdump, poppler_utils, procyon, qemu, R
 , radare2, sng, sqlite, squashfsTools, tcpdump, ubootTools, odt2txt, unzip, wabt, xmlbeans, xxd, xz, zip, zstd
-, enableBloat ? false
+, enableBloat ? true
+, enableUnfree ? false
 # updater only
 , writeScript
 }:
@@ -43,21 +44,32 @@ python3Packages.buildPythonApplication rec {
   # To help figuring out what's missing from the list, run: ./pkgs/tools/misc/diffoscope/list-missing-tools.sh
   #
   # Still missing these tools: docx2txt lipo otool r2pipe
-  pythonPath = [
+  # We filter automatically all packages for the host platform (some dependencies are not supported on Darwin, aarch64, etc.).
+  pythonPath = lib.filter (lib.meta.availableOn stdenv.hostPlatform) ([
       binutils-unwrapped-all-targets bzip2 colordiff coreutils cpio db diffutils
       e2fsprogs file findutils fontforge-fonttools gettext gnutar gzip
       html2text libarchive lz4 openssl pgpdump sng sqlite squashfsTools unzip xxd
-      xz zip zstd
+      xz zip zstd cdrkit dtc
     ]
     ++ (with python3Packages; [
       argcomplete debian defusedxml jsondiff jsbeautifier libarchive-c
-      python-magic progressbar33 pypdf2 tlsh
+      python-magic progressbar33 pypdf2 tlsh pyxattr rpm
     ])
-    ++ lib.optionals stdenv.isLinux [ python3Packages.pyxattr python3Packages.rpm acl cdrkit dtc ]
-    ++ lib.optionals enableBloat ([
-      abootimg apksigcopier apksigner apktool cbfstool colord enjarify ffmpeg fpc ghc ghostscriptX giflib gnupg gnumeric
-      hdf5 imagemagick libcaca llvm jdk mono ocaml odt2txt oggvideotools openssh pdftk poppler_utils procyon qemu R tcpdump ubootTools wabt radare2 xmlbeans
-    ] ++ (with python3Packages; [ androguard binwalk guestfs h5py pdfminer-six ]));
+    ++ lib.optionals enableBloat (
+      [
+        apksigcopier apksigner enjarify ffmpeg fpc ghc ghostscriptX giflib gnupg pdftk
+        hdf5 imagemagick libcaca llvm jdk mono ocaml odt2txt openssh
+        poppler_utils procyon qemu R tcpdump wabt radare2 xmlbeans
+        abootimg cbfstool colord ubootTools
+      ]
+      ++ (with python3Packages; [ androguard binwalk h5py pdfminer-six guestfs ])
+      # oggvideotools is broken on Darwin, please put it back when it will be fixed?
+      ++ lib.optionals stdenv.isLinux [ oggvideotools ]
+      # This doesn't work on aarch64-darwin
+      ++ lib.optionals (stdenv.hostPlatform != "aarch64-darwin") [ gnumeric ]
+      # `apktool` depend on `build-tools` which requires Android SDK acceptance, therefore, the whole thing is unfree.
+      ++ lib.optionals enableUnfree [ apktool ]
+    ));
 
   nativeCheckInputs = with python3Packages; [ pytestCheckHook ] ++ pythonPath;
 
@@ -121,7 +133,7 @@ python3Packages.buildPythonApplication rec {
     '';
     homepage = "https://diffoscope.org/";
     license = licenses.gpl3Plus;
-    maintainers = with maintainers; [ dezgeg danielfullmer ];
+    maintainers = with maintainers; [ dezgeg danielfullmer raitobezarius ];
     platforms = platforms.unix;
   };
 }
diff --git a/pkgs/tools/misc/oggvideotools/default.nix b/pkgs/tools/misc/oggvideotools/default.nix
index e6b8d9a1d288..8a390ad490b6 100644
--- a/pkgs/tools/misc/oggvideotools/default.nix
+++ b/pkgs/tools/misc/oggvideotools/default.nix
@@ -43,5 +43,9 @@ stdenv.mkDerivation rec {
     homepage = "http://www.streamnik.de/oggvideotools.html";
     license = licenses.gpl2Only;
     maintainers = with maintainers; [ SuperSandro2000 ];
+    # Compilation error on Darwin:
+    # error: invalid argument '--std=c++0x' not allowed with 'C'
+    # make[2]: *** [src/libresample/CMakeFiles/resample.dir/build.make:76: src/libresample/CMakeFiles/resample.dir/filterkit.c.o] Error 1
+    broken = stdenv.isDarwin;
   };
 }
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index c8dc0a4052c8..29adbf2e4f15 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -6852,12 +6852,12 @@ with pkgs;
 
   diction = callPackage ../tools/text/diction { };
 
-  diffoscopeMinimal = callPackage ../tools/misc/diffoscope {
+  diffoscope = callPackage ../tools/misc/diffoscope {
     jdk = jdk8;
   };
 
-  diffoscope = diffoscopeMinimal.override {
-    enableBloat = !stdenv.isDarwin;
+  diffoscopeMinimal = diffoscope.override {
+    enableBloat = false;
   };
 
   diffr = callPackage ../tools/text/diffr {