diff --git a/pkgs/development/libraries/grpc/default.nix b/pkgs/development/libraries/grpc/default.nix
index 8cd26ab31052..c00e5a4e0d30 100644
--- a/pkgs/development/libraries/grpc/default.nix
+++ b/pkgs/development/libraries/grpc/default.nix
@@ -17,13 +17,13 @@
 
 stdenv.mkDerivation rec {
   pname = "grpc";
-  version = "1.41.0"; # N.B: if you change this, change pythonPackages.grpcio-tools to a matching version too
+  version = "1.42.0"; # N.B: if you change this, change pythonPackages.grpcio-tools to a matching version too
 
   src = fetchFromGitHub {
     owner = "grpc";
     repo = "grpc";
     rev = "v${version}";
-    sha256 = "1mcgnzwc2mcdpcfhc1b37vff0biwyd3v0a2ack58wgf4336pzlsb";
+    sha256 = "sha256-9/ywbnvd8hqeblFe+X9SM6PkRPB/yqE8Iw9TNmLMSOE=";
     fetchSubmodules = true;
   };
 
diff --git a/pkgs/development/python-modules/grpcio-tools/default.nix b/pkgs/development/python-modules/grpcio-tools/default.nix
index 690e4e8141e6..64874e314484 100644
--- a/pkgs/development/python-modules/grpcio-tools/default.nix
+++ b/pkgs/development/python-modules/grpcio-tools/default.nix
@@ -2,11 +2,11 @@
 
 buildPythonPackage rec {
   pname = "grpcio-tools";
-  version = "1.41.0";
+  version = "1.42.0";
 
   src = fetchPypi {
     inherit pname version;
-    sha256 = "3891b1df82369acbc8451d4952cd20755f49a82398dce62437511ad17b47290e";
+    sha256 = "d0a0daa82eb2c2fb8e12b82a458d1b7c5516fe1135551da92b1a02e2cba93422";
   };
 
   outputs = [ "out" "dev" ];