diff --git a/pkgs/development/python-modules/uvloop/default.nix b/pkgs/development/python-modules/uvloop/default.nix
index 72ede5dc1716..b4b75dbb1941 100644
--- a/pkgs/development/python-modules/uvloop/default.nix
+++ b/pkgs/development/python-modules/uvloop/default.nix
@@ -62,8 +62,12 @@ buildPythonPackage rec {
     "tests/test_sourcecode.py"
   ];
 
-  # force using installed/compiled uvloop vs source by moving tests to temp dir
-  preCheck = ''
+  preCheck = lib.optionalString stdenv.isDarwin ''
+    # Work around "OSError: AF_UNIX path too long"
+    # https://github.com/MagicStack/uvloop/issues/463
+    export TMPDIR="/tmp"
+   '' + ''
+    # force using installed/compiled uvloop vs source by moving tests to temp dir
     export TEST_DIR=$(mktemp -d)
     cp -r tests $TEST_DIR
     pushd $TEST_DIR