diff --git a/pkgs/development/python-modules/flask-restplus/default.nix b/pkgs/development/python-modules/flask-restplus/default.nix
deleted file mode 100644
index 4673daa74644..000000000000
--- a/pkgs/development/python-modules/flask-restplus/default.nix
+++ /dev/null
@@ -1,44 +0,0 @@
-{ lib
-, buildPythonPackage
-, fetchPypi
-, nose
-, blinker
-, tzlocal
-, mock
-, rednose
-, flask
-, six
-, jsonschema
-, pytz
-, aniso8601
-, flask-restful
-, isPy27
-, enum34
-}:
-
-buildPythonPackage rec {
-  pname = "flask-restplus";
-  version = "0.13.0";
-
-  src = fetchPypi {
-    inherit pname version;
-    sha256 = "0p4zz8b5bwbw7w0vhbyihl99d2gw13cb81rxzj4z626a1cnl8vm6";
-  };
-
-  nativeCheckInputs = [ nose blinker tzlocal mock rednose ];
-  propagatedBuildInputs = [ flask six jsonschema pytz aniso8601 flask-restful ]
-   ++ lib.optional isPy27 enum34;
-
-  # RuntimeError: Working outside of application context.
-  doCheck = false;
-
-  checkPhase = ''
-    nosetests
-  '';
-
-  meta = {
-    homepage = "https://github.com/noirbizarre/flask-restplus";
-    description = "Fast, easy and documented API development with Flask";
-    license = lib.licenses.mit;
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 04da6d141ee9..9b9660ec86e5 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -85,6 +85,7 @@ mapAliases ({
   filemagic = throw "inactive since 2014, so use python-magic instead"; # added 2022-11-19
   flaskbabel = flask-babel; # added 2023-01-19
   flask_login = flask-login; # added 2022-10-17
+  flask-restplus = throw "flask-restplus is no longer maintained, use flask-restx instead"; # added 2023-02-21
   flask_sqlalchemy = flask-sqlalchemy; # added 2022-07-20
   flask_testing = flask-testing; # added 2022-04-25
   flask_wtf = flask-wtf; # added 2022-05-24
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 988f7e71981c..80524ff15689 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -3456,8 +3456,6 @@ self: super: with self; {
 
   flask-restful = callPackage ../development/python-modules/flask-restful { };
 
-  flask-restplus = callPackage ../development/python-modules/flask-restplus { };
-
   flask-restx = callPackage ../development/python-modules/flask-restx { };
 
   flask-reverse-proxy-fix = callPackage ../development/python-modules/flask-reverse-proxy-fix { };