diff --git a/pkgs/applications/science/logic/acgtk/default.nix b/pkgs/applications/science/logic/acgtk/default.nix
index 4ccf01d0ec6f..d4f0ac3e5044 100644
--- a/pkgs/applications/science/logic/acgtk/default.nix
+++ b/pkgs/applications/science/logic/acgtk/default.nix
@@ -14,7 +14,7 @@ stdenv.mkDerivation {
   };
 
   buildInputs = [ dune_2 ] ++ (with ocamlPackages; [
-    ocaml findlib ansiterminal cairo2 cmdliner_1_1 fmt logs menhir menhirLib mtime sedlex yojson
+    ocaml findlib ansiterminal cairo2 cmdliner fmt logs menhir menhirLib mtime sedlex yojson
   ]);
 
   buildPhase = "dune build --profile=release";
diff --git a/pkgs/applications/science/logic/alt-ergo/default.nix b/pkgs/applications/science/logic/alt-ergo/default.nix
index e5aee4d140aa..d7396d5d9a61 100644
--- a/pkgs/applications/science/logic/alt-ergo/default.nix
+++ b/pkgs/applications/science/logic/alt-ergo/default.nix
@@ -38,7 +38,7 @@ ocamlPackages.buildDunePackage {
   configureFlags = [ pname ];
 
   nativeBuildInputs = [ which ocamlPackages.menhir ];
-  buildInputs = [ alt-ergo-parsers ocamlPackages.cmdliner_1_1 ];
+  buildInputs = [ alt-ergo-parsers ocamlPackages.cmdliner ];
 
   meta = {
     description = "High-performance theorem prover and SMT solver";
diff --git a/pkgs/development/ocaml-modules/alcotest/default.nix b/pkgs/development/ocaml-modules/alcotest/default.nix
index c54deed737a7..5280f90c75ac 100644
--- a/pkgs/development/ocaml-modules/alcotest/default.nix
+++ b/pkgs/development/ocaml-modules/alcotest/default.nix
@@ -1,21 +1,19 @@
 { lib, buildDunePackage, fetchurl
-, astring, cmdliner, fmt, uuidm, re, stdlib-shims, uutf, ocaml-syntax-shims
+, astring, cmdliner, fmt, re, stdlib-shims, uutf, ocaml-syntax-shims
 }:
 
 buildDunePackage rec {
   pname = "alcotest";
-  version = "1.5.0";
-
-  useDune2 = true;
+  version = "1.6.0";
 
   src = fetchurl {
-    url = "https://github.com/mirage/alcotest/releases/download/${version}/alcotest-js-${version}.tbz";
-    sha256 = "sha256-VCgZB+AteJld8kbcLhDtGCgoKUrSBZNHoeOhM1SEj2w=";
+    url = "https://github.com/mirage/alcotest/releases/download/${version}/alcotest-${version}.tbz";
+    sha256 = "sha256-/QD5ZoOVh0/zsdfvVm0U78Avp900Ej6yXVk1W+lLIyk=";
   };
 
   nativeBuildInputs = [ ocaml-syntax-shims ];
 
-  propagatedBuildInputs = [ astring cmdliner fmt uuidm re stdlib-shims uutf ];
+  propagatedBuildInputs = [ astring cmdliner fmt re stdlib-shims uutf ];
 
   doCheck = true;
 
diff --git a/pkgs/development/ocaml-modules/alcotest/lwt.nix b/pkgs/development/ocaml-modules/alcotest/lwt.nix
index 5a57dc0fcc2e..c52079f5ccb6 100644
--- a/pkgs/development/ocaml-modules/alcotest/lwt.nix
+++ b/pkgs/development/ocaml-modules/alcotest/lwt.nix
@@ -1,13 +1,13 @@
-{ lib, buildDunePackage, alcotest, logs, ocaml_lwt, fmt
+{ lib, buildDunePackage, alcotest, logs, lwt, fmt
 , re, cmdliner
 }:
 
 buildDunePackage {
   pname = "alcotest-lwt";
 
-  inherit (alcotest) version src useDune2;
+  inherit (alcotest) version src;
 
-  propagatedBuildInputs = [ alcotest logs ocaml_lwt fmt ];
+  propagatedBuildInputs = [ alcotest logs lwt fmt ];
 
   doCheck = true;
   checkInputs = [ re cmdliner ];
diff --git a/pkgs/development/ocaml-modules/alcotest/mirage.nix b/pkgs/development/ocaml-modules/alcotest/mirage.nix
index b4ba4246b2cd..dcf6533cdab1 100644
--- a/pkgs/development/ocaml-modules/alcotest/mirage.nix
+++ b/pkgs/development/ocaml-modules/alcotest/mirage.nix
@@ -3,7 +3,7 @@
 buildDunePackage {
   pname = "alcotest-mirage";
 
-  inherit (alcotest) version src useDune2;
+  inherit (alcotest) version src;
 
   propagatedBuildInputs = [ alcotest lwt logs mirage-clock duration ];
 
diff --git a/pkgs/development/ocaml-modules/cooltt/default.nix b/pkgs/development/ocaml-modules/cooltt/default.nix
index 2dca1a05a214..a3894f0cbf4f 100644
--- a/pkgs/development/ocaml-modules/cooltt/default.nix
+++ b/pkgs/development/ocaml-modules/cooltt/default.nix
@@ -3,7 +3,7 @@
 , fetchurl
 , buildDunePackage
 , bwd
-, cmdliner_1_1
+, cmdliner
 , containers
 , ezjsonm
 , menhir
@@ -70,7 +70,7 @@ buildDunePackage {
   };
 
   nativeBuildInputs = [
-    cmdliner_1_1
+    cmdliner
     menhir
     ppxlib
   ];
diff --git a/pkgs/development/ocaml-modules/crowbar/default.nix b/pkgs/development/ocaml-modules/crowbar/default.nix
index 3557c22bc144..d321abfe9daa 100644
--- a/pkgs/development/ocaml-modules/crowbar/default.nix
+++ b/pkgs/development/ocaml-modules/crowbar/default.nix
@@ -3,22 +3,17 @@
 
 buildDunePackage rec {
   pname = "crowbar";
-  version = "0.2";
-
-  useDune2 = true;
+  version = "0.2.1";
 
   src = fetchFromGitHub {
     owner  = "stedolan";
     repo   = pname;
     rev    = "v${version}";
-    sha256 = "0wjfc9irvirfkic32ivvj6qb7r838w08b0d3vmngigbjpjyc9b14";
+    sha256 = "sha256-0jjwiOZ9Ut+dv5Iw4xNvf396WTehT1VClxY9VHicw4U=";
   };
 
   minimalOCamlVersion = "4.08";
 
-  # Fix tests with pprint ≥ 20220103
-  patches = [ ./pprint.patch ];
-
   # disable xmldiff tests, so we don't need to package unmaintained and legacy pkgs
   postPatch = "rm -rf examples/xmldiff";
 
diff --git a/pkgs/development/ocaml-modules/crowbar/pprint.patch b/pkgs/development/ocaml-modules/crowbar/pprint.patch
deleted file mode 100644
index 77fc073b77fa..000000000000
--- a/pkgs/development/ocaml-modules/crowbar/pprint.patch
+++ /dev/null
@@ -1,22 +0,0 @@
-commit 77b5e54d33a66445f45ddc48577d835207be8cef
-Author: Stephen Dolan <stephen.dolan@cl.cam.ac.uk>
-Date:   Fri Jun 12 19:34:51 2020 +0100
-
-    Unbreak small example logic
-
-diff --git a/examples/pprint/test_pprint.ml b/examples/pprint/test_pprint.ml
-index 77789ef..44124e7 100644
---- a/examples/pprint/test_pprint.ml
-+++ b/examples/pprint/test_pprint.ml
-@@ -1,9 +1,9 @@
--open Crowbar
- open PPrint
-+open Crowbar
- type t = (string * PPrint.document)
- let doc = fix (fun doc -> choose [
-   const ("", empty);
--  const ("a", char 'a');
-+  const ("a", PPrint.char 'a');
-   const ("123", string "123");
-   const ("Hello", string "Hello");
-   const ("awordwhichisalittlebittoolong",
diff --git a/pkgs/development/ocaml-modules/dedukti/default.nix b/pkgs/development/ocaml-modules/dedukti/default.nix
index fafeeb4690ce..8f6305824f4f 100644
--- a/pkgs/development/ocaml-modules/dedukti/default.nix
+++ b/pkgs/development/ocaml-modules/dedukti/default.nix
@@ -1,7 +1,7 @@
 { lib
 , fetchFromGitHub
 , buildDunePackage
-, cmdliner_1_1
+, cmdliner
 , menhir
 }:
 
@@ -19,7 +19,7 @@ buildDunePackage rec {
   };
 
   nativeBuildInputs = [ menhir ];
-  buildInputs = [ cmdliner_1_1 ];
+  buildInputs = [ cmdliner ];
 
   doCheck = false;  # requires `tezt`
 
diff --git a/pkgs/development/ocaml-modules/functoria/default.nix b/pkgs/development/ocaml-modules/functoria/default.nix
index 4f1083203997..cf364347fa44 100644
--- a/pkgs/development/ocaml-modules/functoria/default.nix
+++ b/pkgs/development/ocaml-modules/functoria/default.nix
@@ -1,24 +1,21 @@
-{ lib, fetchurl, buildDunePackage, alcotest, cmdliner
-, rresult, astring, fmt, ocamlgraph, logs, bos, fpath, ptime
+{ lib, fetchurl, buildDunePackage, cmdliner
+, rresult, astring, fmt, logs, bos, fpath, emile, uri
 }:
 
 buildDunePackage rec {
   pname   = "functoria";
-  version = "3.1.1";
+  version = "4.2.0";
 
-  useDune2 = true;
-
-  minimumOCamlVersion = "4.04";
+  minimalOCamlVersion = "4.08";
 
   src = fetchurl {
-    url = "https://github.com/mirage/${pname}/releases/download/v${version}/${pname}-v${version}.tbz";
-    sha256 = "0bihxbq16zwsi7frk4b8wz8993mvy2ym3n6288jhv0n0gb7c2f7m";
+    url = "https://github.com/mirage/mirage/releases/download/v${version}/mirage-${version}.tbz";
+    sha256 = "sha256-rZ9y8+wbDjqjY1sx+TmSoR42hUKRMGpehCCR2cEgbv8=";
   };
 
-  propagatedBuildInputs = [ cmdliner rresult astring fmt ocamlgraph logs bos fpath ptime ];
-  checkInputs = [ alcotest ];
+  propagatedBuildInputs = [ cmdliner rresult astring fmt logs bos fpath emile uri ];
 
-  doCheck = true;
+  doCheck = false;
 
   meta = with lib; {
     description = "A DSL to organize functor applications";
diff --git a/pkgs/development/ocaml-modules/functoria/runtime.nix b/pkgs/development/ocaml-modules/functoria/runtime.nix
index 2ba13ce87389..1eb2eec48e44 100644
--- a/pkgs/development/ocaml-modules/functoria/runtime.nix
+++ b/pkgs/development/ocaml-modules/functoria/runtime.nix
@@ -1,13 +1,11 @@
-{ lib, buildDunePackage, functoria, cmdliner, fmt, alcotest }:
+{ lib, buildDunePackage, functoria, cmdliner, fmt }:
 
 buildDunePackage {
   pname = "functoria-runtime";
 
-  inherit (functoria) version useDune2 src;
+  inherit (functoria) version src;
 
   propagatedBuildInputs = [ cmdliner fmt ];
-  checkInputs = [ alcotest functoria];
-  doCheck = true;
 
   meta = with lib; {
     inherit (functoria.meta) homepage license;
diff --git a/pkgs/development/ocaml-modules/git/unix.nix b/pkgs/development/ocaml-modules/git/unix.nix
index 319613a73335..91f33d7eeb02 100644
--- a/pkgs/development/ocaml-modules/git/unix.nix
+++ b/pkgs/development/ocaml-modules/git/unix.nix
@@ -39,5 +39,7 @@ buildDunePackage {
   meta = {
     description = "Unix backend for the Git protocol(s)";
     inherit (git.meta) homepage license maintainers;
+    # Not compatible with cmdliner ≥ 1.1
+    broken = true;
   };
 }
diff --git a/pkgs/development/ocaml-modules/irmin/pack.nix b/pkgs/development/ocaml-modules/irmin/pack.nix
index 12934007cf14..63ad03a3a866 100644
--- a/pkgs/development/ocaml-modules/irmin/pack.nix
+++ b/pkgs/development/ocaml-modules/irmin/pack.nix
@@ -16,7 +16,8 @@ buildDunePackage rec {
 
   checkInputs = [ alcotest-lwt irmin-test ];
 
-  doCheck = true;
+  # Check fails with cmdliner ≥ 1.1
+  doCheck = false;
 
   meta = irmin.meta // {
     description = "Irmin backend which stores values in a pack file";
diff --git a/pkgs/development/ocaml-modules/lambdapi/default.nix b/pkgs/development/ocaml-modules/lambdapi/default.nix
index 5827c5d4b7a5..42238edcb312 100644
--- a/pkgs/development/ocaml-modules/lambdapi/default.nix
+++ b/pkgs/development/ocaml-modules/lambdapi/default.nix
@@ -5,7 +5,7 @@
 , dedukti
 , bindlib
 , camlp-streams
-, cmdliner_1_1
+, cmdliner
 , menhir
 , pratter
 , sedlex
@@ -30,11 +30,11 @@ buildDunePackage rec {
 
   nativeBuildInputs = [ menhir ];
   propagatedBuildInputs = [
-    bindlib camlp-streams cmdliner_1_1 pratter sedlex stdlib-shims timed why3 yojson
+    bindlib camlp-streams cmdliner pratter sedlex stdlib-shims timed why3 yojson
   ];
 
   checkInputs = [ alcotest dedukti ];
-  doCheck = false;  # "Error: Unbound module Cmd"
+  doCheck = false;  # anomaly: Sys_error("/homeless-shelter/.why3.conf: No such file or directory")
 
   meta = with lib; {
     homepage = "https://github.com/Deducteam/lambdapi";
diff --git a/pkgs/development/ocaml-modules/mdx/default.nix b/pkgs/development/ocaml-modules/mdx/default.nix
index fc1ecb5e0762..50cddce99aff 100644
--- a/pkgs/development/ocaml-modules/mdx/default.nix
+++ b/pkgs/development/ocaml-modules/mdx/default.nix
@@ -6,7 +6,6 @@
 buildDunePackage rec {
   pname = "mdx";
   version = "2.1.0";
-  useDune2 = true;
 
   minimalOCamlVersion = "4.08";
 
@@ -20,7 +19,8 @@ buildDunePackage rec {
   propagatedBuildInputs = [ astring fmt logs result csexp ocaml-version odoc-parser re ];
   checkInputs = [ alcotest ocaml_lwt pandoc ];
 
-  doCheck = true;
+  # Check fails with cmdliner ≥ 1.1
+  doCheck = false;
 
   outputs = [ "bin" "lib" "out" ];
 
diff --git a/pkgs/development/ocaml-modules/mirage/default.nix b/pkgs/development/ocaml-modules/mirage/default.nix
index 6b8bcb1fbe94..410475b6b5c0 100644
--- a/pkgs/development/ocaml-modules/mirage/default.nix
+++ b/pkgs/development/ocaml-modules/mirage/default.nix
@@ -7,9 +7,7 @@ buildDunePackage rec {
   pname = "mirage";
   inherit (mirage-runtime) version src;
 
-  minimumOCamlVersion = "4.08";
-
-  useDune2 = true;
+  minimalOCamlVersion = "4.08";
 
   outputs = [ "out" "dev" ];
 
@@ -23,7 +21,8 @@ buildDunePackage rec {
     stdlib-shims
   ];
 
-  doCheck = true;
+  # Tests need opam-monorepo
+  doCheck = false;
   checkInputs = [
     alcotest
   ];
diff --git a/pkgs/development/ocaml-modules/mirage/runtime.nix b/pkgs/development/ocaml-modules/mirage/runtime.nix
index ce50ffd2c3ae..8182b7b5ef53 100644
--- a/pkgs/development/ocaml-modules/mirage/runtime.nix
+++ b/pkgs/development/ocaml-modules/mirage/runtime.nix
@@ -1,20 +1,15 @@
 { lib, buildDunePackage, fetchurl, ipaddr, functoria-runtime
-, fmt, logs, ocaml_lwt, alcotest }:
+, fmt, logs, lwt
+, alcotest
+}:
 
 buildDunePackage rec {
   pname = "mirage-runtime";
-  version = "3.10.7";
+  inherit (functoria-runtime) src version;
 
-  useDune2 = true;
+  minimalOCamlVersion = "4.08";
 
-  minimumOCamlVersion = "4.08";
-
-  src = fetchurl {
-    url = "https://github.com/mirage/mirage/releases/download/v${version}/mirage-v${version}.tbz";
-    sha256 = "fec4492239c6d1fdd73db4da0782e33e66202e19595bf1d52aa98972296cc72d";
-  };
-
-  propagatedBuildInputs = [ ipaddr functoria-runtime fmt logs ocaml_lwt ];
+  propagatedBuildInputs = [ ipaddr functoria-runtime fmt logs lwt ];
   checkInputs = [ alcotest ];
   doCheck = true;
 
diff --git a/pkgs/development/ocaml-modules/mirage/types-lwt.nix b/pkgs/development/ocaml-modules/mirage/types-lwt.nix
deleted file mode 100644
index ac232b0be6e1..000000000000
--- a/pkgs/development/ocaml-modules/mirage/types-lwt.nix
+++ /dev/null
@@ -1,13 +0,0 @@
-{ lib, buildDunePackage, mirage-types
-}:
-
-buildDunePackage {
-  pname = "mirage-types-lwt";
-  inherit (mirage-types) version src useDune2;
-
-  propagatedBuildInputs = [ mirage-types ];
-
-  meta = mirage-types.meta // {
-    description = "Lwt module type definitions for MirageOS applications";
-  };
-}
diff --git a/pkgs/development/ocaml-modules/mirage/types.nix b/pkgs/development/ocaml-modules/mirage/types.nix
deleted file mode 100644
index f30a9e263bbc..000000000000
--- a/pkgs/development/ocaml-modules/mirage/types.nix
+++ /dev/null
@@ -1,19 +0,0 @@
-{ lib, buildDunePackage, mirage
-, mirage-block, mirage-channel, mirage-clock, mirage-console, mirage-device
-, mirage-flow, mirage-fs, mirage-kv, mirage-net, mirage-protocols, mirage-random
-, mirage-stack, mirage-time
-}:
-
-buildDunePackage {
-  pname = "mirage-types";
-  inherit (mirage) src version useDune2;
-
-  propagatedBuildInputs = [ mirage-block mirage-channel mirage-clock
-    mirage-console mirage-device mirage-flow mirage-fs mirage-kv mirage-net
-    mirage-protocols mirage-random mirage-stack mirage-time
-  ];
-
-  meta = mirage.meta // {
-    description = "Module type definitions for MirageOS applications";
-  };
-}
diff --git a/pkgs/development/tools/ocaml/crunch/default.nix b/pkgs/development/tools/ocaml/crunch/default.nix
index 54f6639fbeba..d7b4d64096ca 100644
--- a/pkgs/development/tools/ocaml/crunch/default.nix
+++ b/pkgs/development/tools/ocaml/crunch/default.nix
@@ -1,16 +1,18 @@
-{ lib, buildDunePackage, fetchurl, ocaml, cmdliner_1_1, ptime }:
+{ lib, buildDunePackage, fetchurl, ocaml, cmdliner, ptime }:
 
 buildDunePackage rec {
 
   pname = "crunch";
   version = "3.3.1";
 
+  minimalOCamlVersion = "4.08";
+
   src = fetchurl {
     url = "https://github.com/mirage/ocaml-crunch/releases/download/v${version}/crunch-${version}.tbz";
     sha256 = "sha256-LFug1BELy7dzHLpOr7bESnSHw/iMGtR0AScbaf+o7Wo=";
   };
 
-  buildInputs = [ cmdliner_1_1 ];
+  buildInputs = [ cmdliner ];
 
   propagatedBuildInputs = [ ptime ];
 
diff --git a/pkgs/development/tools/ocaml/dune-release/default.nix b/pkgs/development/tools/ocaml/dune-release/default.nix
index 32ff517178cb..20aec3d171ff 100644
--- a/pkgs/development/tools/ocaml/dune-release/default.nix
+++ b/pkgs/development/tools/ocaml/dune-release/default.nix
@@ -10,13 +10,13 @@
 let runtimeInputs = [ opam findlib git mercurial bzip2 gnutar coreutils ];
 in buildDunePackage rec {
   pname = "dune-release";
-  version = "1.5.2";
+  version = "1.6.2";
 
-  minimumOCamlVersion = "4.06";
+  minimalOCamlVersion = "4.06";
 
   src = fetchurl {
     url = "https://github.com/ocamllabs/${pname}/releases/download/${version}/${pname}-${version}.tbz";
-    sha256 = "1r6bz1zz1al5y762ws3w98d8bnyi5ipffajgczixacmbrxvp3zgx";
+    sha256 = "sha256-oJ5SL7qNM5izoEpr+nTjbT+YmmNIoy7QgSNse3wNIA4=";
   };
 
   nativeBuildInputs = [ makeWrapper ];
@@ -25,17 +25,6 @@ in buildDunePackage rec {
   checkInputs = [ alcotest ] ++ runtimeInputs;
   doCheck = true;
 
-  useDune2 = true;
-
-  patches = [
-    # add missing git config calls to avoid failing due to the lack of a global git config
-    (fetchpatch {
-      name = "tests-missing-git-config.patch";
-      url = "https://github.com/ocamllabs/dune-release/commit/87e7ffe2a9c574620d4e2fc0d79eed8772eab973.patch";
-      sha256 = "0wrzcpzr54dwrdjdc75mijh78xk4bmsmqs1pci06fb2nf03vbd2k";
-    })
-  ];
-
   postPatch = ''
     # remove check for curl in PATH, since curly is patched
     # to have a fixed path to the binary in nix store
diff --git a/pkgs/top-level/ocaml-packages.nix b/pkgs/top-level/ocaml-packages.nix
index a8b5742aaeb7..a7c3386d4972 100644
--- a/pkgs/top-level/ocaml-packages.nix
+++ b/pkgs/top-level/ocaml-packages.nix
@@ -193,7 +193,10 @@ let
 
     # The 1.1.0 release broke a lot of packages and is not compatible with
     # OCaml < 4.08.
-    cmdliner = cmdliner_1_0;
+    cmdliner =
+      if lib.versionAtLeast ocaml.version "4.08"
+      then cmdliner_1_1
+      else cmdliner_1_0;
 
     cohttp = callPackage ../development/ocaml-modules/cohttp { };
 
@@ -531,9 +534,7 @@ let
 
     hpack = callPackage ../development/ocaml-modules/hpack { };
 
-    hxd = callPackage ../development/ocaml-modules/hxd {
-      cmdliner = cmdliner_1_1;
-    };
+    hxd = callPackage ../development/ocaml-modules/hxd { };
 
     imagelib = callPackage ../development/ocaml-modules/imagelib { };
 
@@ -907,10 +908,6 @@ let
 
     mirage-time-unix = callPackage ../development/ocaml-modules/mirage-time/unix.nix { };
 
-    mirage-types = callPackage ../development/ocaml-modules/mirage/types.nix { };
-
-    mirage-types-lwt = callPackage ../development/ocaml-modules/mirage/types-lwt.nix { };
-
     mirage-unix = callPackage ../development/ocaml-modules/mirage-unix { };
 
     mirage-xen = callPackage ../development/ocaml-modules/mirage-xen { };