diff --git a/pkgs/development/python-modules/cacheyou/default.nix b/pkgs/development/python-modules/cacheyou/default.nix
deleted file mode 100644
index 375beadd4f6d..000000000000
--- a/pkgs/development/python-modules/cacheyou/default.nix
+++ /dev/null
@@ -1,62 +0,0 @@
-{ lib
-, buildPythonPackage
-, cherrypy
-, fetchPypi
-, filelock
-, msgpack
-, pdm-backend
-, pytestCheckHook
-, pythonOlder
-, redis
-, requests
-}:
-
-buildPythonPackage rec {
-  pname = "cacheyou";
-  version = "23.3";
-  format = "pyproject";
-
-  disabled = pythonOlder "3.7";
-
-  __darwinAllowLocalNetworking = true;
-
-  src = fetchPypi {
-    inherit pname version;
-    hash = "sha256-fkCPFfSXj+oiR3NLMIYh919/4Wm0YWeVGccuioXWHV0=";
-  };
-
-  nativeBuildInputs = [
-    pdm-backend
-  ];
-
-  propagatedBuildInputs = [
-    msgpack
-    requests
-  ];
-
-  passthru.optional-dependencies = {
-    filecache = [
-      filelock
-    ];
-    redis = [
-      redis
-    ];
-  };
-
-  nativeCheckInputs = [
-    cherrypy
-    pytestCheckHook
-  ] ++ passthru.optional-dependencies.filecache;
-
-  pythonImportsCheck = [
-    "cacheyou"
-  ];
-
-  meta = {
-    description = "The httplib2 caching algorithms packaged up for use with requests";
-    homepage = "https://github.com/frostming/cacheyou";
-    changelog = "https://github.com/frostming/cacheyou/releases/tag/${version}";
-    license = lib.licenses.asl20;
-    maintainers = with lib.maintainers; [ natsukium ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index fc1cd2d4a174..5fe0e98b9a2d 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -76,6 +76,7 @@ mapAliases ({
   buildbot-pkg = throw "buildbot-pkg has been removed, it's only internally used in buildbot"; # added 2022-04-07
   bt_proximity = bt-proximity; # added 2021-07-02
   BTrees = btrees; # added 2023-02-19
+  cacheyou = throw "cacheyou has been removed, as it was no longer used for the only consumer pdm"; # added 2023-12-21
   carrot = throw "carrot has been removed, as its development was discontinued in 2012"; # added 2022-01-18
   cchardet = faust-cchardet; # added 2023-03-02
   class-registry = phx-class-registry; # added 2021-10-05
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 02fb6a00b055..9cc0aec97ed1 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -1759,8 +1759,6 @@ self: super: with self; {
 
   cachey = callPackage ../development/python-modules/cachey { };
 
-  cacheyou = callPackage ../development/python-modules/cacheyou { };
-
   cachier = callPackage ../development/python-modules/cachier { };
 
   cachy = callPackage ../development/python-modules/cachy { };