diff --git a/pkgs/tools/audio/yabridge/default.nix b/pkgs/tools/audio/yabridge/default.nix
new file mode 100644
index 000000000000..56f6cddb61ed
--- /dev/null
+++ b/pkgs/tools/audio/yabridge/default.nix
@@ -0,0 +1,127 @@
+{ lib
+, stdenv
+, fetchFromGitHub
+, meson
+, ninja
+, pkg-config
+, wine
+, boost
+, libxcb
+}:
+
+let
+  # Derived from subprojects/bitsery.wrap
+  bitsery = rec {
+    version = "5.2.0";
+    src = fetchFromGitHub {
+      owner = "fraillt";
+      repo = "bitsery";
+      rev = "v${version}";
+      sha256 = "132b0n0xlpcv97l6bhk9n57hg95pkhwqzvr9jkv57nmggn76s5q7";
+    };
+  };
+
+  # Derived from subprojects/function2.wrap
+  function2 = rec {
+    version = "4.1.0";
+    src = fetchFromGitHub {
+      owner = "Naios";
+      repo = "function2";
+      rev = version;
+      sha256 = "0abrz2as62725g212qswi35nsdlf5wrhcz78hm2qidbgqr9rkir5";
+    };
+  };
+
+  # Derived from subprojects/tomlplusplus.wrap
+  tomlplusplus = rec {
+    version = "2.1.0";
+    src = fetchFromGitHub {
+      owner = "marzer";
+      repo = "tomlplusplus";
+      rev = "v${version}";
+      sha256 = "0fspinnpyk1c9ay0h3wl8d4bbm6aswlypnrw2c7pk2i4mh981b4b";
+    };
+  };
+
+  # Derived from vst3.wrap
+  vst3 = rec {
+    version = "e2fbb41f28a4b311f2fc7d28e9b4330eec1802b6";
+    src = fetchFromGitHub {
+      owner = "robbert-vdh";
+      repo = "vst3sdk";
+      rev = version;
+      fetchSubmodules = true;
+      sha256 = "1fqpylkbljifwdw2z75agc0yxnhmv4b09fxs3rvlw1qmm5mwx0p2";
+    };
+  };
+in stdenv.mkDerivation rec {
+  pname = "yabridge";
+  version = "3.0.0";
+
+  # NOTE: Also update yabridgectl's cargoSha256 when this is updated
+  src = fetchFromGitHub {
+    owner = "robbert-vdh";
+    repo = pname;
+    rev = version;
+    sha256 = "0ha7jhnkd2i49q5rz2hp7sq6hv19bir99x51hs6nvvcf16hlf2bp";
+  };
+
+  # Unpack subproject sources
+  postUnpack = ''(
+    cd "$sourceRoot/subprojects"
+    cp -R --no-preserve=mode,ownership ${bitsery.src} bitsery-${bitsery.version}
+    tar -xf bitsery-patch-${bitsery.version}.tar.xz
+    cp -R --no-preserve=mode,ownership ${function2.src} function2-${function2.version}
+    tar -xf function2-patch-${function2.version}.tar.xz
+    cp -R --no-preserve=mode,ownership ${tomlplusplus.src} tomlplusplus
+    cp -R --no-preserve=mode,ownership ${vst3.src} vst3
+  )'';
+
+  postPatch = ''
+    patchShebangs .
+  '';
+
+  nativeBuildInputs = [
+    meson
+    ninja
+    pkg-config
+    wine
+  ];
+
+  buildInputs = [
+    boost
+    libxcb
+  ];
+
+  # Meson is no longer able to pick up Boost automatically.
+  # https://github.com/NixOS/nixpkgs/issues/86131
+  BOOST_INCLUDEDIR = "${lib.getDev boost}/include";
+  BOOST_LIBRARYDIR = "${lib.getLib boost}/lib";
+
+  mesonFlags = [
+    "--cross-file" "cross-wine.conf"
+
+    # Requires CMake and is unnecessary
+    "-Dtomlplusplus:GENERATE_CMAKE_CONFIG=disabled"
+
+    # tomlplusplus examples and tests don't build with winegcc
+    "-Dtomlplusplus:BUILD_EXAMPLES=disabled"
+    "-Dtomlplusplus:BUILD_TESTS=disabled"
+  ];
+
+  installPhase = ''
+    mkdir -p "$out/bin" "$out/lib"
+    cp yabridge-group.exe{,.so} "$out/bin"
+    cp yabridge-host.exe{,.so} "$out/bin"
+    cp libyabridge-vst2.so "$out/lib"
+    cp libyabridge-vst3.so "$out/lib"
+  '';
+
+  meta = with lib; {
+    description = "Yet Another VST bridge, run Windows VST2 plugins under Linux";
+    homepage = "https://github.com/robbert-vdh/yabridge";
+    license = licenses.gpl3Plus;
+    maintainers = with maintainers; [ metadark ];
+    platforms = [ "x86_64-linux" ];
+  };
+}
diff --git a/pkgs/tools/audio/yabridgectl/default.nix b/pkgs/tools/audio/yabridgectl/default.nix
new file mode 100644
index 000000000000..6fa85cd89e8b
--- /dev/null
+++ b/pkgs/tools/audio/yabridgectl/default.nix
@@ -0,0 +1,23 @@
+{ lib, rustPlatform, yabridge }:
+
+rustPlatform.buildRustPackage rec {
+  pname = "yabridgectl";
+  version = yabridge.version;
+
+  src = yabridge.src;
+  sourceRoot = "source/tools/yabridgectl";
+  cargoSha256 = "1sjhani8h7ap42yqlnj05sx59jyz2h12qlm1ibv8ldxcpwps0bwy";
+
+  patches = [
+    ./libyabridge-from-nix-profiles.patch
+  ];
+
+  patchFlags = [ "-p3" ];
+
+  meta = with lib; {
+    description = "A small, optional utility to help set up and update yabridge for several directories at once";
+    homepage = "https://github.com/robbert-vdh/yabridge/tree/master/tools/yabridgectl";
+    license = licenses.gpl3Plus;
+    maintainers = with maintainers; [ metadark ];
+  };
+}
diff --git a/pkgs/tools/audio/yabridgectl/libyabridge-from-nix-profiles.patch b/pkgs/tools/audio/yabridgectl/libyabridge-from-nix-profiles.patch
new file mode 100644
index 000000000000..e17cda6ada33
--- /dev/null
+++ b/pkgs/tools/audio/yabridgectl/libyabridge-from-nix-profiles.patch
@@ -0,0 +1,70 @@
+diff --git a/tools/yabridgectl/src/config.rs b/tools/yabridgectl/src/config.rs
+index c1c89cf..d7bd822 100644
+--- a/tools/yabridgectl/src/config.rs
++++ b/tools/yabridgectl/src/config.rs
+@@ -23,6 +23,7 @@ use std::collections::{BTreeMap, BTreeSet};
+ use std::env;
+ use std::fmt::Display;
+ use std::fs;
++use std::iter;
+ use std::path::{Path, PathBuf};
+ use which::which;
+ use xdg::BaseDirectories;
+@@ -216,34 +217,24 @@ impl Config {
+                 }
+             }
+             None => {
+-                // Search in the system library locations and in `~/.local/share/yabridge` if no
+-                // path was set explicitely. We'll also search through `/usr/local/lib` just in case
+-                // but since we advocate against installing yabridge there we won't list this path
+-                // in the error message when `libyabridge-vst2.so` can't be found.
+-                let system_path = Path::new("/usr/lib");
++                // Search through NIX_PROFILES & data home directory if no path was set explicitly.
++                let nix_profiles = env::var("NIX_PROFILES");
+                 let user_path = xdg_dirs.get_data_home();
+-                let lib_directories = [
+-                    system_path,
+-                    // Used on Debian based distros
+-                    Path::new("/usr/lib/x86_64-linux-gnu"),
+-                    // Used on Fedora
+-                    Path::new("/usr/lib64"),
+-                    Path::new("/usr/local/lib"),
+-                    Path::new("/usr/local/lib/x86_64-linux-gnu"),
+-                    Path::new("/usr/local/lib64"),
+-                    &user_path,
+-                ];
++                let lib_directories = nix_profiles.iter()
++                    .flat_map(|profiles| profiles.split(' ')
++                              .map(|profile| Path::new(profile).join("lib")))
++                    .chain(iter::once(user_path.clone()));
++
+                 let mut candidates = lib_directories
+-                    .iter()
+                     .map(|directory| directory.join(LIBYABRIDGE_VST2_NAME));
++
+                 match candidates.find(|directory| directory.exists()) {
+                     Some(candidate) => candidate,
+                     _ => {
+                         return Err(anyhow!(
+-                            "Could not find '{}' in either '{}' or '{}'. You can override the \
+-                            default search path using 'yabridgectl set --path=<path>'.",
++                            "Could not find '{}' through 'NIX_PROFILES' or '{}'. You can override the \
++                             default search path using 'yabridgectl set --path=<path>'.",
+                             LIBYABRIDGE_VST2_NAME,
+-                            system_path.display(),
+                             user_path.display()
+                         ));
+                     }
+diff --git a/tools/yabridgectl/src/main.rs b/tools/yabridgectl/src/main.rs
+index 0db1bd4..221cdd0 100644
+--- a/tools/yabridgectl/src/main.rs
++++ b/tools/yabridgectl/src/main.rs
+@@ -102,7 +102,7 @@ fn main() -> Result<()> {
+                         .about("Path to the directory containing 'libyabridge-{vst2,vst3}.so'")
+                         .long_about(
+                             "Path to the directory containing 'libyabridge-{vst2,vst3}.so'. If this \
+-                             is not set, then yabridgectl will look in both '/usr/lib' and \
++                             is not set, then yabridgectl will look through 'NIX_PROFILES' and \
+                              '~/.local/share/yabridge' by default.",
+                         )
+                         .validator(validate_path)
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index b7aabc2afa3a..9645e0feb0f8 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -748,6 +748,12 @@ in
 
   metapixel = callPackage ../tools/graphics/metapixel { };
 
+  yabridge = callPackage ../tools/audio/yabridge {
+    wine = wineWowPackages.minimal;
+  };
+
+  yabridgectl = callPackage ../tools/audio/yabridgectl { };
+
   ### APPLICATIONS/TERMINAL-EMULATORS
 
   alacritty = callPackage ../applications/terminal-emulators/alacritty {