diff --git a/pkgs/development/python-modules/pygame/default.nix b/pkgs/development/python-modules/pygame/default.nix
index bcdce070c633..7ae4c96702ad 100644
--- a/pkgs/development/python-modules/pygame/default.nix
+++ b/pkgs/development/python-modules/pygame/default.nix
@@ -1,6 +1,6 @@
-{ lib, fetchPypi, buildPythonPackage, python, pkg-config, libX11
-, SDL2, SDL2_image, SDL2_mixer, SDL2_ttf, libpng, libjpeg, portmidi, freetype
-, fontconfig
+{ stdenv, lib, substituteAll, fetchPypi, buildPythonPackage, python, pkg-config, libX11
+, SDL2, SDL2_image, SDL2_mixer, SDL2_ttf, libpng, libjpeg, portmidi, freetype, fontconfig
+, AppKit, CoreMIDI
 }:
 
 buildPythonPackage rec {
@@ -12,6 +12,27 @@ buildPythonPackage rec {
     sha256 = "8b1e7b63f47aafcdd8849933b206778747ef1802bd3d526aca45ed77141e4001";
   };
 
+  patches = [
+    # Patch pygame's dependency resolution to let it find build inputs
+    (substituteAll {
+      src = ./fix-dependency-finding.patch;
+      buildinputs_include = builtins.toJSON (builtins.concatMap (dep: [
+        "${lib.getDev dep}/"
+        "${lib.getDev dep}/include"
+      ]) buildInputs);
+      buildinputs_lib = builtins.toJSON (builtins.concatMap (dep: [
+        "${lib.getLib dep}/"
+        "${lib.getLib dep}/lib"
+      ]) buildInputs);
+    })
+  ];
+
+  postPatch = ''
+    substituteInPlace src_py/sysfont.py \
+      --replace 'path="fc-list"' 'path="${fontconfig}/bin/fc-list"' \
+      --replace /usr/X11/bin/fc-list ${fontconfig}/bin/fc-list
+  '';
+
   nativeBuildInputs = [
     pkg-config SDL2
   ];
@@ -19,37 +40,33 @@ buildPythonPackage rec {
   buildInputs = [
     SDL2 SDL2_image SDL2_mixer SDL2_ttf libpng libjpeg
     portmidi libX11 freetype
+  ] ++ lib.optionals stdenv.isDarwin [
+    AppKit CoreMIDI
   ];
 
   preConfigure = ''
-    sed \
-      -e "s/origincdirs = .*/origincdirs = []/" \
-      -e "s/origlibdirs = .*/origlibdirs = []/" \
-      -e "/linux-gnu/d" \
-      -i buildconfig/config_unix.py
-    ${lib.concatMapStrings (dep: ''
-      sed \
-        -e "/origincdirs =/a\        origincdirs += ['${lib.getDev dep}/include']" \
-        -e "/origlibdirs =/a\        origlibdirs += ['${lib.getLib dep}/lib']" \
-        -i buildconfig/config_unix.py
-      '') buildInputs
-    }
     LOCALBASE=/ ${python.interpreter} buildconfig/config.py
   '';
 
-  checkInputs = [ fontconfig ];
+  checkPhase = ''
+    runHook preCheck
 
-  preCheck = ''
     # No audio or video device in test environment
     export SDL_VIDEODRIVER=dummy
     export SDL_AUDIODRIVER=disk
     export SDL_DISKAUDIOFILE=/dev/null
+
+    ${python.interpreter} -m pygame.tests -v --exclude opengl,timing --time_out 300
+
+    runHook postCheck
   '';
+  pythonImportsCheck = [ "pygame" ];
 
   meta = with lib; {
     description = "Python library for games";
     homepage = "https://www.pygame.org/";
     license = licenses.lgpl21Plus;
-    platforms = platforms.linux;
+    maintainers = with maintainers; [ angustrau ];
+    platforms = platforms.unix;
   };
 }
diff --git a/pkgs/development/python-modules/pygame/fix-dependency-finding.patch b/pkgs/development/python-modules/pygame/fix-dependency-finding.patch
new file mode 100644
index 000000000000..11b705f1b1ad
--- /dev/null
+++ b/pkgs/development/python-modules/pygame/fix-dependency-finding.patch
@@ -0,0 +1,64 @@
+diff --git a/buildconfig/config_darwin.py b/buildconfig/config_darwin.py
+index 8d84683f..70df8f9c 100644
+--- a/buildconfig/config_darwin.py
++++ b/buildconfig/config_darwin.py
+@@ -56,10 +56,10 @@ class Dependency:
+ class FrameworkDependency(Dependency):
+     def configure(self, incdirs, libdirs):
+         BASE_DIRS = '/', os.path.expanduser('~/'), '/System/'
+-        for n in BASE_DIRS:
++        for n in incdirs + libdirs:
+             n += 'Library/Frameworks/'
+             fmwk = n + self.libs + '.framework/Versions/Current/'
+-            if os.path.isfile(fmwk + self.libs):
++            if os.path.isfile(fmwk + self.libs + '.tbd'):
+                 print ('Framework ' + self.libs + ' found')
+                 self.found = 1
+                 self.inc_dir = fmwk + 'Headers'
+@@ -158,19 +158,8 @@ def main(sdl2=False):
+     ])
+ 
+     print ('Hunting dependencies...')
+-    incdirs = ['/usr/local/include']
+-    if sdl2:
+-        incdirs.append('/usr/local/include/SDL2')
+-    else:
+-        incdirs.append('/usr/local/include/SDL')
+-
+-    incdirs.extend([
+-       #'/usr/X11/include',
+-       '/opt/local/include',
+-       '/opt/local/include/freetype2/freetype']
+-    )
+-    #libdirs = ['/usr/local/lib', '/usr/X11/lib', '/opt/local/lib']
+-    libdirs = ['/usr/local/lib', '/opt/local/lib']
++    incdirs = @buildinputs_include@
++    libdirs = @buildinputs_lib@
+ 
+     for d in DEPS:
+         if isinstance(d, (list, tuple)):
+diff --git a/buildconfig/config_unix.py b/buildconfig/config_unix.py
+index f6a4ea4b..f7f5be76 100644
+--- a/buildconfig/config_unix.py
++++ b/buildconfig/config_unix.py
+@@ -224,18 +224,8 @@ def main(sdl2=False):
+     if not DEPS[0].found:
+         raise RuntimeError('Unable to run "sdl-config". Please make sure a development version of SDL is installed.')
+ 
+-    incdirs = []
+-    libdirs = []
+-    for extrabase in extrabases:
+-        incdirs += [extrabase + d for d in origincdirs]
+-        libdirs += [extrabase + d for d in origlibdirs]
+-    incdirs += ["/usr"+d for d in origincdirs]
+-    libdirs += ["/usr"+d for d in origlibdirs]
+-    incdirs += ["/usr/local"+d for d in origincdirs]
+-    libdirs += ["/usr/local"+d for d in origlibdirs]
+-    if localbase:
+-        incdirs = [localbase+d for d in origincdirs]
+-        libdirs = [localbase+d for d in origlibdirs]
++    incdirs = @buildinputs_include@
++    libdirs = @buildinputs_lib@
+ 
+     for arg in DEPS[0].cflags.split():
+         if arg[:2] == '-I':
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 86042f35b2b2..d69614c78f3a 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -6079,7 +6079,9 @@ in {
 
   pygal = callPackage ../development/python-modules/pygal { };
 
-  pygame = callPackage ../development/python-modules/pygame { };
+  pygame = callPackage ../development/python-modules/pygame {
+    inherit (pkgs.darwin.apple_sdk.frameworks) AppKit CoreMIDI;
+  };
 
   pygame_sdl2 = callPackage ../development/python-modules/pygame_sdl2 { };