diff --git a/pkgs/build-support/cc-wrapper/default.nix b/pkgs/build-support/cc-wrapper/default.nix
index 35d714f9b41e..b011322aa3dd 100644
--- a/pkgs/build-support/cc-wrapper/default.nix
+++ b/pkgs/build-support/cc-wrapper/default.nix
@@ -15,7 +15,7 @@
 , propagateDoc ? cc != null && cc ? man
 , extraTools ? [], extraPackages ? [], extraBuildCommands ? ""
 , nixSupport ? {}
-, isGNU ? false, isClang ? cc.isClang or false, gnugrep ? null
+, isGNU ? false, isClang ? cc.isClang or false, isCcache ? cc.isCcache or false, gnugrep ? null
 , buildPackages ? {}
 , libcxx ? null
 }:
@@ -178,7 +178,7 @@ stdenv.mkDerivation {
         local dst="$1"
         local wrapper="$2"
         export prog="$3"
-        export use_response_file_by_default=${if isClang then "1" else "0"}
+        export use_response_file_by_default=${if isClang && !isCcache then "1" else "0"}
         substituteAll "$wrapper" "$out/bin/$dst"
         chmod +x "$out/bin/$dst"
       }
diff --git a/pkgs/development/tools/misc/ccache/default.nix b/pkgs/development/tools/misc/ccache/default.nix
index 98ae2d42ba40..22345023c366 100644
--- a/pkgs/development/tools/misc/ccache/default.nix
+++ b/pkgs/development/tools/misc/ccache/default.nix
@@ -76,6 +76,7 @@ let ccache = stdenv.mkDerivation rec {
       passthru = {
         isClang = unwrappedCC.isClang or false;
         isGNU = unwrappedCC.isGNU or false;
+        isCcache = true;
       };
       inherit (unwrappedCC) lib;
       nativeBuildInputs = [ makeWrapper ];