diff --git a/pkgs/development/python-modules/pex/default.nix b/pkgs/development/python-modules/pex/default.nix
index 78bb61d03cfb..0bbbf551f280 100644
--- a/pkgs/development/python-modules/pex/default.nix
+++ b/pkgs/development/python-modules/pex/default.nix
@@ -6,11 +6,11 @@
 
 buildPythonPackage rec {
   pname = "pex";
-  version = "2.1.20";
+  version = "2.1.21";
 
   src = fetchPypi {
     inherit pname version;
-    sha256 = "2f1cf9721aa5fce93b034d2a18922d34d6f5fb81236ab3a955706226b15658fd";
+    sha256 = "d580a26da1b342ab2ebbf675ba2bab04e98c4d1aaf2a6fea09f41d68dfc466ba";
   };
 
   nativeBuildInputs = [ setuptools ];