diff --git a/pkgs/development/python-modules/pylibjpeg/default.nix b/pkgs/development/python-modules/pylibjpeg/default.nix
new file mode 100644
index 000000000000..65055d94280c
--- /dev/null
+++ b/pkgs/development/python-modules/pylibjpeg/default.nix
@@ -0,0 +1,69 @@
+{ stdenv
+, lib
+, buildPythonPackage
+, fetchFromGitHub
+, pythonOlder
+, pytestCheckHook
+, setuptools
+, numpy
+, pydicom
+, pylibjpeg-libjpeg
+}:
+
+let
+  pylibjpeg-data = buildPythonPackage rec {
+    pname = "pylibjpeg-data";
+    version = "1.0.0dev0";
+    pyproject = true;
+
+    nativeBuildInputs = [ setuptools ];
+
+    src = fetchFromGitHub {
+      owner = "pydicom";
+      repo = "pylibjpeg-data";
+      rev = "2ab4b8a65b070656eca2582bd23197a3d01cdccd";
+      hash = "sha256-cFE1XjrqyGqwHCYGRucXK+q4k7ftUIbYwBw4WwIFtEc=";
+    };
+
+    doCheck = false;
+  };
+in
+
+buildPythonPackage rec {
+  pname = "pylibjpeg";
+  version = "1.4.0";
+  pyproject = true;
+
+  disabled = pythonOlder "3.7";
+
+  src = fetchFromGitHub {
+    owner = "pydicom";
+    repo = "pylibjpeg";
+    rev = "refs/tags/v${version}";
+    hash = "sha256-Px1DyYDkKAUdYo+ZxZ1w7TkPzWN++styiFl02iQOvyQ=";
+  };
+
+  nativeBuildInputs = [ setuptools ];
+
+  propagatedBuildInputs = [ numpy ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+    pydicom
+    pylibjpeg-data
+    pylibjpeg-libjpeg
+  ];
+
+  pythonImportsCheck = [ "pylibjpeg" ];
+
+  meta = with lib; {
+    description = "Python framework for decoding JPEG images, with a focus on supporting Pydicom";
+    homepage = "https://github.com/pydicom/pylibjpeg";
+    changelog = "https://github.com/pydicom/pylibjpeg/releases/tag/v${version}";
+    license = licenses.mit;
+    maintainers = with maintainers; [ bcdarwin ];
+    # several test failures of form
+    # "pydicom.errors.InvalidDicomError: File is missing DICOM File Meta Information header or the 'DICM' prefix is missing from the header. ..."
+    broken = stdenv.isDarwin;
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 3f42299fb536..fd3decd1dc25 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -10602,6 +10602,8 @@ self: super: with self; {
     inherit (pkgs) libusb1;
   };
 
+  pylibjpeg = callPackage ../development/python-modules/pylibjpeg { };
+
   pylibjpeg-libjpeg = callPackage ../development/python-modules/pylibjpeg-libjpeg { };
 
   pyliblo = callPackage ../development/python-modules/pyliblo { };