diff --git a/pkgs/applications/networking/p2p/twister/default.nix b/pkgs/applications/networking/p2p/twister/default.nix
deleted file mode 100644
index 979ac955caf3..000000000000
--- a/pkgs/applications/networking/p2p/twister/default.nix
+++ /dev/null
@@ -1,70 +0,0 @@
-{ lib, stdenv, fetchFromGitHub, fetchpatch, autoconf, automake, libtool, pkg-config, python2
-, boost, db, openssl, geoip, libiconv, miniupnpc, srcOnly
-}:
-
-let
-  twisterHTML = srcOnly {
-    name = "twister-html";
-    src = fetchFromGitHub {
-      owner = "miguelfreitas";
-      repo = "twister-html";
-      rev = "01e7f7ca9b7e42ed90f91bc42da2c909ca5c0b9b";
-      sha256 = "sha256-Hi/VAEwujWhKAPaYIuvrxRIuPQa9AYwXiHUGbWxckmk=";
-    };
-  };
-
-  boostPython = boost.override {
-    enablePython = true;
-    python = python2;
-  };
-
-in stdenv.mkDerivation rec {
-  pname = "twister";
-  version = "2019-08-19";
-
-  src = fetchFromGitHub {
-    owner = "miguelfreitas";
-    repo = "twister-core";
-    rev = "31faf3f63e461ea0a9b23081567a4a552cf06873";
-    sha256 = "0xh1lgnl9nd86jr0mp7m8bkd7r5j4d6chd0y73h2xv4aq5sld0sp";
-  };
-
-  configureFlags = [
-    "--with-libgeoip"
-    "--with-libiconv"
-    "--disable-deprecated-functions"
-    "--enable-tests"
-    "--enable-python-binding"
-    "--with-boost-libdir=${boostPython.out}/lib"
-  ];
-
-  nativeBuildInputs = [ pkg-config automake autoconf ];
-  buildInputs = [
-    libtool python2
-    boostPython db openssl geoip miniupnpc libiconv
-  ];
-
-  postPatch = ''
-    sed -i -e '/-htmldir/s|(default: [^)]*)|(default: ${twisterHTML})|' \
-      src/init.cpp
-    sed -i -e '/GetDataDir.*html/s|path *= *[^;]*|path = "${twisterHTML}"|' \
-      src/util.cpp
-  '';
-
-  preConfigure = ''
-    sh autotool.sh
-  '';
-
-  installPhase = ''
-    install -vD twisterd "$out/bin/twisterd"
-  '';
-
-  enableParallelBuilding = true;
-
-  meta = {
-    homepage = "http://www.twister.net.co/";
-    description = "Peer-to-peer microblogging";
-    license = lib.licenses.mit;
-    platforms = lib.platforms.linux;
-  };
-}
diff --git a/pkgs/top-level/aliases.nix b/pkgs/top-level/aliases.nix
index 2822ea4619af..394a1ca83b78 100644
--- a/pkgs/top-level/aliases.nix
+++ b/pkgs/top-level/aliases.nix
@@ -1308,6 +1308,7 @@ mapAliases ({
   tshark = throw "'tshark' has been renamed to/replaced by 'wireshark-cli'"; # Converted to throw 2022-02-22
   tuijam = throw "tuijam has been removed because Google Play Music was discontinued"; # Added 2021-03-07
   turbo-geth = throw "turbo-geth has been renamed to erigon"; # Added 2021-08-08
+  twister = throw "twister has been removed: abandoned by upstream and python2-only"; # Added 2022-04-26
   typora = throw "Newer versions of typora use anti-user encryption and refuse to start. As such it has been removed"; # Added 2021-09-11
 
   ### U ###
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 4e4e37c9dc89..557953fb4451 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -30069,10 +30069,6 @@ with pkgs;
     swt = swt_jdk8;
   };
 
-  twister = callPackage ../applications/networking/p2p/twister {
-    boost = boost16x;
-  };
-
   twmn = libsForQt5.callPackage ../applications/misc/twmn { };
 
   testssl = callPackage ../applications/networking/testssl { };