diff --git a/pkgs/development/libraries/jemalloc/default.nix b/pkgs/development/libraries/jemalloc/default.nix
index a2812a9c6677..cb734508b340 100644
--- a/pkgs/development/libraries/jemalloc/default.nix
+++ b/pkgs/development/libraries/jemalloc/default.nix
@@ -33,6 +33,9 @@ stdenv.mkDerivation rec {
     # AArch64 has configurable page size up to 64k. The default configuration
     # for jemalloc only supports 4k page sizes.
     ++ lib.optional stdenv.isAarch64 "--with-lg-page=16"
+    # See https://github.com/jemalloc/jemalloc/issues/1997
+    # Using a value of 48 should work on both emulated and native x86_64-darwin.
+    ++ lib.optional (stdenv.isDarwin && stdenv.isx86_64) "--with-lg-vaddr=48"
   ;
 
   NIX_CFLAGS_COMPILE = lib.optionalString stdenv.isDarwin "-Wno-error=array-bounds";