diff --git a/pkgs/applications/emulators/pcsx2/default.nix b/pkgs/applications/emulators/pcsx2/default.nix
index 34eba5ed7819..953fd3a3daa2 100644
--- a/pkgs/applications/emulators/pcsx2/default.nix
+++ b/pkgs/applications/emulators/pcsx2/default.nix
@@ -1,90 +1,110 @@
-{ alsa-lib
-, cmake
+{ cmake
 , fetchFromGitHub
+, lib
+, stdenv
+, curl
+, ffmpeg
 , fmt
 , gettext
-, glib
-, gtk3
 , harfbuzz
-, lib
 , libaio
+, libbacktrace
 , libpcap
-, libpng
 , libpulseaudio
 , libsamplerate
-, libXdmcp
-, openssl
-, pcre
-, perl
+, libXrandr
+, libzip
 , pkg-config
-, portaudio
+, qtbase
+, qtsvg
+, qttools
+, qttranslations
+, qtwayland
+, rapidyaml
 , SDL2
 , soundtouch
-, stdenv
-, udev
 , vulkan-headers
 , vulkan-loader
-, wrapGAppsHook
-, wxGTK
-, zlib
 , wayland
+, wrapQtAppsHook
+, xz
+, zip
 }:
 
+let
+  # The pre-zipped files in releases don't have a versioned link, we need to zip them ourselves
+  pcsx2_patches = fetchFromGitHub {
+    owner = "PCSX2";
+    repo = "pcsx2_patches";
+    rev = "8db5ae467a35cc00dc50a65061aa78dc5115e6d1";
+    sha256 = "sha256-68kD7IAhBMASFmkGwvyQ7ppO/3B1csAKik+rU792JI4=";
+  };
+in
 stdenv.mkDerivation rec {
   pname = "pcsx2";
-  version = "1.7.3331";
-  # nixpkgs-update: no auto update
+  version = "1.7.4554";
 
   src = fetchFromGitHub {
     owner = "PCSX2";
     repo = "pcsx2";
     fetchSubmodules = true;
     rev = "v${version}";
-    hash = "sha256-0RcmBMxKj/gnkNEjn2AUSSO1DzyNSf1lOZWPSUq6764=";
+    sha256 = "sha256-9MRbpm7JdVmZwv8zD4lErzVTm7A4tYM0FgXE9KpX+/8=";
   };
 
   cmakeFlags = [
     "-DDISABLE_ADVANCE_SIMD=TRUE"
-    "-DDISABLE_PCSX2_WRAPPER=TRUE"
-    "-DPACKAGE_MODE=TRUE"
-    "-DWAYLAND_API=TRUE"
-    "-DXDG_STD=TRUE"
-    "-DUSE_VULKAN=TRUE"
+    "-DUSE_SYSTEM_LIBS=ON"
+    "-DDISABLE_BUILD_DATE=TRUE"
   ];
 
-  nativeBuildInputs = [ cmake perl pkg-config vulkan-headers wrapGAppsHook ];
+  nativeBuildInputs = [ cmake pkg-config wrapQtAppsHook zip ];
 
   buildInputs = [
-    alsa-lib
+    curl
+    ffmpeg
     fmt
     gettext
-    glib
-    gtk3
     harfbuzz
     libaio
+    libbacktrace
     libpcap
-    libpng
     libpulseaudio
     libsamplerate
-    libXdmcp
-    openssl
-    pcre
-    portaudio
+    libXrandr
+    libzip
+    qtbase
+    qtsvg
+    qttools
+    qttranslations
+    qtwayland
+    rapidyaml
     SDL2
     soundtouch
-    udev
+    vulkan-headers
     vulkan-loader
     wayland
-    wxGTK
-    zlib
+    xz
   ];
 
-  preFixup = ''
-    gappsWrapperArgs+=(
-      --prefix LD_LIBRARY_PATH : ${lib.makeLibraryPath [ vulkan-loader ]}
-    )
+  installPhase = ''
+    mkdir -p $out/bin
+    cp -a bin/pcsx2-qt bin/resources $out/bin/
+
+    install -Dm644 $src/pcsx2/Resources/AppIcon64.png $out/share/pixmaps/PCSX2.png
+    install -Dm644 $src/.github/workflows/scripts/linux/pcsx2-qt.desktop $out/share/applications/PCSX2.desktop
+
+    zip -jq $out/bin/resources/patches.zip ${pcsx2_patches}/patches/*
   '';
 
+  qtWrapperArgs = [
+    "--prefix LD_LIBRARY_PATH : ${lib.makeLibraryPath [
+      ffmpeg # It's loaded with dlopen. They plan to change it https://github.com/PCSX2/pcsx2/issues/8624
+      libpulseaudio
+      vulkan-loader
+    ]}"
+  ];
+
   meta = with lib; {
     description = "Playstation 2 emulator";
     longDescription = ''
@@ -95,13 +115,9 @@ stdenv.mkDerivation rec {
       PC, with many additional features and benefits.
     '';
     homepage = "https://pcsx2.net";
+    license = with licenses; [ gpl3 lgpl3 ];
     maintainers = with maintainers; [ hrdinka govanify ];
-
-    # PCSX2's source code is released under LGPLv3+. It However ships
-    # additional data files and code that are licensed differently.
-    # This might be solved in future, for now we should stick with
-    # license.free
-    license = licenses.free;
+    mainProgram = "pcsx2-qt";
     platforms = platforms.x86_64;
   };
 }
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 8935f14f8b82..911f5df257b2 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -2399,9 +2399,7 @@ with pkgs;
 
   pcem = callPackage ../applications/emulators/pcem { };
 
-  pcsx2 = callPackage ../applications/emulators/pcsx2 {
-    wxGTK = wxGTK32;
-  };
+  pcsx2 = qt6Packages.callPackage ../applications/emulators/pcsx2 { };
 
   pcsxr = callPackage ../applications/emulators/pcsxr { };