diff --git a/pkgs/development/python-modules/pyspx/default.nix b/pkgs/development/python-modules/pyspx/default.nix
new file mode 100644
index 000000000000..b8e3cb49df6f
--- /dev/null
+++ b/pkgs/development/python-modules/pyspx/default.nix
@@ -0,0 +1,47 @@
+{ lib
+, buildPythonPackage
+, cffi
+, fetchFromGitHub
+, pytestCheckHook
+, pythonOlder
+, setuptools
+, wheel
+}:
+
+buildPythonPackage rec {
+  pname = "pyspx";
+  version = "0.5.2";
+  pyproject = true;
+
+  disabled = pythonOlder "3.7";
+
+  src = fetchFromGitHub {
+    owner = "sphincs";
+    repo = "pyspx";
+    rev = "refs/tags/v${version}";
+    hash = "sha256-hMZ7JZoo5RdUwQYpGjtZznH/O6rBUXv+svfOAI0cjqs=";
+    fetchSubmodules = true;
+  };
+
+  nativeBuildInputs = [
+    cffi
+    setuptools
+    wheel
+  ];
+
+  nativeCheckInputs = [
+    pytestCheckHook
+  ];
+
+  pythonImportsCheck = [
+    "pyspx"
+  ];
+
+  meta = with lib; {
+    description = "Python bindings for SPHINCS";
+    homepage = "https://github.com/sphincs/pyspx";
+    changelog = "https://github.com/sphincs/pyspx/releases/tag/v${version}";
+    license = licenses.cc0;
+    maintainers = with maintainers; [ fab ];
+  };
+}
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index d28185ab184c..2eb45e6c7780 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -11086,6 +11086,8 @@ self: super: with self; {
 
   pysptk = callPackage ../development/python-modules/pysptk { };
 
+  pyspx = callPackage ../development/python-modules/pyspx { };
+
   pysqlcipher3 = callPackage ../development/python-modules/pysqlcipher3 {
     inherit (pkgs) sqlcipher;
   };