IPv6 Configuration IPv6 is enabled by default. Stateless address autoconfiguration is used to automatically assign IPv6 addresses to all interfaces, and Privacy Extensions (RFC 4946) are enabled by default. You can adjust the default for this by setting . This option may be overridden on a per-interface basis by . You can disable IPv6 support globally by setting: networking.enableIPv6 = false; You can disable IPv6 on a single interface using a normal sysctl (in this example, we use interface eth0): boot.kernel.sysctl."net.ipv6.conf.eth0.disable_ipv6" = true; As with IPv4 networking interfaces are automatically configured via DHCPv6. You can configure an interface manually: networking.interfaces.eth0.ipv6.addresses = [ { address = "fe00:aa:bb:cc::2"; prefixLength = 64; } ]; For configuring a gateway, optionally with explicitly specified interface: networking.defaultGateway6 = { address = "fe00::1"; interface = "enp0s3"; }; See for similar examples and additional information.